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Hippocampal involvement in the acquisition of relational associations, but not in the expression of a transitive inference task in mice
Journal Contribution - Journal Article
The hippocampus (HC) has been suggested to play a role in transitive inference (TI) on an ordered
sequence of stimuli. However, it has remained unclear whether HC is involved in the expression of TI,
or rather contributes to TI through its role in the acquisition of the sequence of elements (Frank, Rudy,
& O’Reilly, 2003). Presently, the authors compared the effects of excitotoxic dorsal HC lesions in C57BL
mice that received surgery before or after they were trained to discriminate between pairs of visual
stimuli. Performance on a subsequent TI task was worse in mice with pretraining lesions than in those
with posttraining lesions, which showed similar performance to shams without lesions. This indicates that
HC is not involved in the expression of TI, but may merely help to acquire the underlying representations
required for TI.
Journal: Behavioral Neuroscience
ISSN: 0735-7044
Issue: 1
Volume: 123
Pages: 109 - 114
Publication year:2009
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:1
CSS-citation score:1
Authors from:Higher Education
Accessibility:Closed