The study of granule biogenesis during megakaryopoiesis from insights of known and novel genetic granule deficiencies

The overall objective of this project is to use an MK model to discover novel molecular pathways underlying the clinical phenotypes of isolated and syndromic inherited platelet granule deficiencies by combining next generation sequencing and functional platelet data, using improved in vitro MK models obtained via inducible pluripotent stem cells and building novel sensitive and dynamic microscopy techniques for the studies of granule biogenesis.