Sensor development for targeted detection of DNA mutations in extracellular vesicles (R-8530)

Early diagnosis and targeted therapy are crucial for successful cancer treatments. Detection of tumor-related mutations in genetic material are crucial in this context, not only for diagnosis, but also to follow the disease progression and for the identification of (new) therapeutic targets. This PhD aims to provide a new technique for mutation analysis, by enrichment of tumor-derived nucleic acid present in extracellular vesicles and hybridization-based detection of mutated nucleic acids on an impedimetric sensor platform. It is a collaboration between Hasselt University, VITO (Flemish Institute for Technological Research) and KU Leuven.

Keywords:Sensor development

Disciplines:Applied mathematics in specific fields, Astronomy and space sciences, Classical physics, Materials physics, Mathematical physics, Quantum physics