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Entry of feline infectious peritonitis virus in blood monocytes Universiteit Gent
Feline coronaviruses occur in two virulence variants of which the feline infectious peritonitis virus (FIPV) is the most threatening. It causes a monocyte-derived viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To address this matter, an improved knowledge of the pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the ...
The CD147 protein complex is involved in entry of Chikungunya virus and related alphaviruses in human cells Universiteit Gent Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Sialoadhesin and CD163, a dynamic duo involved in porcine reproductive and respiratory syndrome virus entry in macrophages and possible targeting molecules Universiteit Gent
The porcine reproductive and respiratory syndrome virus (PRRSV), which is spread across swine-producing countries, is the economically most important viral pig disease. To further improve PRRSV-management tools, knowledge is required on essential aspects of PRRSV’s life cycle. Much effort is already put into the investigation of PRRSV entry, with an important milestone being identification of the siglec sialoadhesin as a macrophage-restricted ...
Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry Universiteit Gent
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells Instituut voor Tropische Geneeskunde
Zika virus (ZIKV) is a historically neglected mosquito-borne flavivirus that has caused recent epidemics in the western hemisphere. ZIKV has been associated with severe symptoms including infant microcephaly and Guillain-Barré syndrome, stimulating interest in understanding factors governing ZIKV infection. Heat shock protein 70 (Hsp70) has been shown to be an infection factor for multiple viruses, leading us to investigate the role of Hsp70 ...
Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes Universiteit Gent
Emerging options for interfering with influenza virus entry and replication KU Leuven
Influenza viruses are highly contagious respiratory pathogens with considerable medical and socio-economical burden, whether in the context of the seasonal influenza epidemics or the unpredictable, yet potentially, severe pandemics. The current influenza vaccines require annual updating and provide only partial protection. Hence, antiviral drugs are an essential component in the prevention and treatment of influenza virus infections. At the ...
Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors KU Leuven
Currently, there are only three FDA-approved drugs that inhibit human immunodeficiency virus (HIV) entry-fusion into host cells. The situation is even worse for enterovirus EV71 infection for which no antiviral therapies are available. We describe here the discovery of potent entry dual inhibitors of HIV and EV71. These compounds contain in their structure three or four tryptophan (Trp) residues linked to a central scaffold. Critical for ...
Entry inhibitors for human respiratory virus SARS-CoV-2. KU Leuven
Despite the clear success of the administered COVID-19 vaccines, we still cannot control the spread of SARS-CoV-2, as evidenced by the current circulation of the highly contagious Omicron variant. This highlights the need to continue with the development of effective broad-spectrum antivirals that can be used to rapidly diminish viral spread when an epidemic with a (re-)emerging virus occurs. Candidate SARS-CoV-2 inhibitors should show broad ...