Cis-regulatory mapping of the RPE-expressed transcription factor OTX2 Universiteit Gent
Vakgroep Pediatrie en genetica, Vakgroep Oogheelkunde, Radboud University Nijmegen, Inserm, Avacta (United Kingdom), Telethon Foundation, University of Tübingen, University of Leeds
Corbo et al. (2010) mapped CRX bound cis-regulatory elements in mouse, resulting in a photoreceptor-specific regulatory map. Retinal pigment epithelium (RPE)-expressed genes are not represented in this dataset. ChIP-seq of the RPE-expressed transcription factor OTX2 will be performed in RPE-derived cell lines. Exomes data of index cases with retinal dystrophies (RD) will be filtered against known RD genes, and against CRX, NRL and OTX2 ...