PREDICTIVE PERFORMANCES OF DIFFERENT THERAPEUTIC DRUG MONITORING APPROACHES TO ASSESS TACROLIMUS AND MYCOPHENOLIC ACID EXPOSURE Vrije Universiteit Brussel
Objective: Mycophenolic acid (MPA) and Tacrolimus (TAC) are immunosuppressive drugs routinely used after solid organ transplantation. MPA and TAC have a rather narrow therapeutic window and their pharmacokinetics show considerable variability. In most centers, TDM is frequently performed based only on trough concentrations (C(0)). The main objective of the present study was to compare performances of three different approaches of C(0) based TDM ...