Publicaties
Dried blood microsampling-based therapeutic drug monitoring of antiepileptic drugs in children with nodding syndrome and epilepsy in Uganda and the Democratic Republic of the Congo Universiteit Gent Universiteit Antwerpen
Influence of interactions between immunosuppressive drugs on therapeutic drug monitoring KU Leuven
With the emergence of more immunosuppressive drug combinations in transplantation, the number and complexity of drug interactions have increased and constitute a growing challenge for clinicians. Especially, clinically relevant immunosuppressive drug interactions require prompt. identification, intensified monitoring of drug concentrations and adequate dosing responses.
Fully automated therapeutic drug monitoring of anti-epileptic drugs making use of dried blood spots Universiteit Gent
Volumetric absorptive microsampling as an alternative tool for therapeutic drug monitoring of first-generation anti-epileptic drugs Universiteit Gent
Therapeutic Drug Monitoring During Induction of Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease: Defining a Therapeutic Drug Window KU Leuven
Anti-tumor necrosis factor (TNF) therapy has revolutionized the treatment of inflammatory bowel disease (IBD). However, up to 30% of patients with IBD show no clinical benefit and are defined as having a primary nonresponse. Primary nonresponse to a biologic can be attributed to either pharmacokinetic or pharmacodynamic issues, such as those involved in secondary loss of response. Pharmacokinetic issues are linked to undetectable or ...
Therapeutic drug monitoring of second-generation antipsychotics for the estimation of early drug effect in first-episode psychosis Universiteit Antwerpen
Therapeutic drug monitoring in inflammatory bowel disease: current state and future perspectives KU Leuven
Current available anti-inflammatory drugs, in particular monoclonal antibodies directed against the cytokine tumor necrosis factor α (TNF), have greatly enhanced the treatment of inflammatory bowel diseases (IBD). Although many patients respond to ant-TNF therapy, a proportion of patients will not respond (primary non-response) or will lose response to the drug over time (secondary non-response). This loss of response can be caused by patient, ...
Therapeutic drug monitoring of enteric-coated mycophenolate sodium by limited sampling strategies is associated with a high rate of failure Vrije Universiteit Brussel Universiteit Antwerpen
Background: Therapeutic drug monitoring of mycophenolic acid (MPA) is usually performed with a limited sampling strategy (LSS), which relies on a limited number of blood samples and subsequent extrapolation of the global exposure to MPA. LSS is usually performed successfully with mycophenolate mofetil (MMF), but data on enteric-coated mycophenolate sodium (EC-MPS) are scarce. Here, we evaluated the feasibility of 6-h LSS therapeutic drug ...
Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation KU Leuven
Mycophenolate mofetil (MMF) is widely used for maintenance immunosuppressive therapy in pediatric renal and heart transplant recipients. Children undergo developmental changes (ontogeny) of drug disposition, which may affect drug metabolism of the active compound mycophenolic acid (MPA). Therefore, a detailed characterization of MPA pharmacokinetics and pharmacodynamics in this patient population is required. In general, the overall efficacy and ...