Publicaties
Design, synthesis, and antimycobacterial evaluation of novel tetrahydroisoquinoline hydrazide analogs Universiteit Antwerpen
Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds Vrije Universiteit Brussel
Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma Vrije Universiteit Brussel
PURPOSE: No standard salvage chemotherapy has been identified for metastatic pancreatic adenocarcinoma (mPA), and there is an urgent need for active agents against this disease. This phase II trial explored the activity of trabectedin in mPA progressing after gemcitabine-based first-line chemotherapy.
METHODS: Patients with gemcitabine-resistant disease received trabectedin 1.3 mg/m(2) as a 3-h intravenous continuous infusion every 3 ...
Synthesis of N-substituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones Vrije Universiteit Brussel
Synthesis of 1-(para-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes KU Leuven
Divergent and Nucleophile-Assisted Rearrangement in the Construction of Pyrrolo[2,1-b][3]benzazepine and Pyrido[2,1-a]isoquinoline Scaffolds KU Leuven
Gold(I)-catalyzed synthesis of dihydrodibenzoquinolizinium salts Vrije Universiteit Brussel
A gold-catalyzed cyclization of 1-alkynyl-2-aryl tetrahydroisoquinolines is described for the synthesis of novel dihydrodibenzoquinolizinium salts. The reaction mechanism is likely to involve a 6-endo-dig cyclization and subsequent oxidation by air to give a relatively stable arylgold intermediate. This gold species undergoes protodeauration under acidic conditions to afford the title compounds. An NMR study was performed to gain further ...