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Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies Universiteit Antwerpen
Background A minority of HIV-1 infected individuals develop broad cross-neutralizing (BCN) plasma antibodies that are capable of neutralizing a spectrum of virus variants belonging to different HIV-1 clades. The aim of this study was to identify the targeted epitopes of an individual with BCN plasma antibodies, referred to as ITM4, using peptide phage display. This study also aimed to use the selected mimotopes as tools to unravel the evolution ...
Neutralizing antibody patterns in sera of individuals infected with human immunodeficiency virus (HIV) type 1, HIV-2 and simian immunodeficiency virus (SIVcpz) to their homologous and heterologous isolates Instituut voor Tropische Geneeskunde
Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA Universiteit Gent
Placental malaria is a major health problem for both pregnant women and their fetuses in malaria endemic regions. It is triggered by the accumulation of Plasmodium falciparum-infected erythrocytes (IE) in the intervillous spaces of the placenta and is associated with foetal growth restriction and maternal anemia. IE accumulation is supported by the binding of the parasite-expressed protein VAR2CSA to placental chondroitin sulfate A (CSA). ...
Utilizing Nanobody Technology to Target Non- Immunodominant Domains of VAR2CSA Vrije Universiteit Brussel
Placental malaria is a major health problem for both pregnant women and their fetuses in malaria endemic regions. It is triggered by the accumulation of Plasmodium falciparum-infected erythrocytes (IE) in the intervillous spaces of the placenta and is associated with foetal growth restriction and maternal anemia. IE accumulation is supported by the binding of the parasite-expressed protein VAR2CSA to placental chondroitin sulfate A (CSA). ...
Border Sensitive Centralities in Patent Citation Networks Using Asymmetric Random Walks KU Leuven
Growth and innovation in particular sectors of the economy can be spurred by funding from governments or firms with the initial investment producing spillovers into other sectors of the economy. Funding sectors that are central to the economy are expected to produce more or greater spillovers than if more peripheral sectors were funded. If the funding body is a national government, it is desirable that spillovers remain primarily in the domestic ...
Stability analysis of the coexistence equilibrium of a balanced metapopulation model Universiteit Gent
We analyze the stability of a unique coexistence equilibrium point of a system of ordinary differential equations (ODE system) modelling the dynamics of a metapopulation, more specifically, a set of local populations inhabiting discrete habitat patches that are connected to one another through dispersal or migration. We assume that the inter-patch migrations are detailed balanced and that the patches are identical with intra-patch dynamics ...
An Accurate and Efficient Yield Optimization Method for Analog Circuits Based on Computing Budget Allocation and Memetic Search Technique KU Leuven
Monte-Carlo (MC) simulation is still the most commonly used technique for yield estimation of analog integrated circuits, because of its generality and accuracy. However, although some speed acceleration methods for MC simulation have been proposed, their efficiency is not high enough for MC-based yield optimization (determines optimal device sizes and optimizes yield at the same time), which requires repeated yield calculations. In this paper, ...
Understanding public acceptance of elite sport policy in japan: a structural equation modelling approach Vrije Universiteit Brussel
INTRODUCTION
Increased investment in elite sport often results in the achievement of more medals in international sporting events (Hogan & Norton, 2000; Li, Meng, & Wang, 2009), or is essential even to maintain existing performance levels (De Bosscher, Bingham, Shibli, van Bottenburg, & De Knop, 2008). This generates a weighty debate about the 'never-ending spending race' (Mitchell, Spong, & Stewart, 2012). The current ...
Increased investment in elite sport often results in the achievement of more medals in international sporting events (Hogan & Norton, 2000; Li, Meng, & Wang, 2009), or is essential even to maintain existing performance levels (De Bosscher, Bingham, Shibli, van Bottenburg, & De Knop, 2008). This generates a weighty debate about the 'never-ending spending race' (Mitchell, Spong, & Stewart, 2012). The current ...
Fast Finite Element Simulation Using GPGPU Technology in Soft Tissue Biomechanics KU Leuven
Finite element analysis (FEA) enjoys a variety of applications in the field of biomechanics, from simulated fatigue testing of an intramedullary rod to studying stresses in a displacement field generated within a single cell. The powerful generality of the finite element method implies that often no purpose-specific method or model need be developed to study a system, but regrettably also implies a certain computational cost. FEA-supported ...