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PREVENTION OF TUNNELED CUFFED CATHETER DYSFUNCTION WITH PROPHYLACTIC USE OF TAUROLIDINE LOCKING SOLUTION CONTAINING UROKINASE: A PROSPECTIVE AND RANDOMIZED PLACEBO-CONTROLLED TRIAL Vrije Universiteit Brussel
Urokinase-containing locking solution in the prevention of dialysis catheter dysfunction: a double blind randomized controlled trial Vrije Universiteit Brussel Universiteit Gent Universiteit Antwerpen
Introduction: The prophylactic use of recombinant tissue plasminogen activator once weekly reduces the incidence rate of tunneled cuffed catheter (TCC) malfunction and bacteremia as compared to the exclusive use of heparin as locking solution. Restricting the use of prophylactic thrombolytic agents to patients with a history of thrombotic TCC malfunction could be more cost effective. We conduct a multicenter, double-blind, randomized ...