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Therapeutic drug monitoring of enteric-coated mycophenolate sodium by limited sampling strategies is associated with a high rate of failure Vrije Universiteit Brussel Universiteit Antwerpen

Jean-Michel Hougardy, Laurette Maufort, Frederic Cotton, Julien Coussement, Dimitri Mikhalski, Karl Martin Wissing, Daniel Abramowicz
Background: Therapeutic drug monitoring of mycophenolic acid (MPA) is usually performed with a limited sampling strategy (LSS), which relies on a limited number of blood samples and subsequent extrapolation of the global exposure to MPA. LSS is usually performed successfully with mycophenolate mofetil (MMF), but data on enteric-coated mycophenolate sodium (EC-MPS) are scarce. Here, we evaluated the feasibility of 6-h LSS therapeutic drug ...

External validation of the endometriosis fertility index (EFI) staging system for predicting non-ART pregnancy after endometriosis surgery Universiteit Hasselt KU Leuven

C. Tomassetti, B. Geysenbergh, Christel Meuleman, D. Timmerman, Steffen FIEUWS, T. D'Hooghe
Can the ability of the endometriosis fertility index (EFI) to predict non-assisted reproductive technology (ART) pregnancy after endometriosis surgery be confirmed by an external validation study? The significant relationship between the EFI score and the time to non-ART pregnancy observed in our study represents an external validation of this scoring system. The EFI was previously developed and tested prospectively in a single center, but up to ...

Increased levels of sST2 in patients with mitral annulus disjunction and ventricular arrhythmias. Vrije Universiteit Brussel

LA Dejgaard, E Skjølsvik, OH Lie, Andreea-Iulia Motoc, E HOPP, T Ueland, Carlos Collet, M Ribe, T Edvardsen, KH Haugga, et al.

Objective Displacement of the mitral valve, mitral annulus disjunction (MAD), is described as a possible aetiology of sudden cardiac death. Stress-induced fibrosis in the mitral valve apparatus has been suggested as the underlying mechanism. We aimed to explore the association between stretch-related and fibrosis-related biomarkers and ventricular arrhythmias in MAD. We hypothesised that soluble suppression of tumourigenicity-2 (sST2) and ...

Immuniteit, het Epstein-Barr virus en de micro-omgeving in lymfomen: karakterisatie van lymfoïde weefsels en rationale voor nieuwe therapeutische opportuniteiten KU Leuven

Lukas Marcelis
For this PhD thesis we studied a set of rare B-cell lymphoproliferative disorders (LPDs): immunomodulation related lymphoproliferative disorders (IARLPD) and primary central nervous system lymphoma (PCNSL) using both classical and novel pathology techniques. We are currently expanding upon this research with an ongoing project studying EBV+ diffuse large B-cell lymphoma (EBV+ DLBCL). All with the aim of aiding the correct implementation of novel ...

Myeloid-derived suppressor cells at diagnosis may discriminate between benign and malignant ovarian tumors KU Leuven

An Coosemans, Jolien Ceusters, Pieter Busschaert, Wouter Froyman, Ben Van Calster, Dirk Timmerman
BACKGROUND: The behavior of the immune system as a driver in the progression of ovarian cancer has barely been studied. Our knowledge is mainly limited to the intra-tumoral adaptive immune system. Because of the widespread metastases of ovarian cancer, an assessment of the circulating immune system seems more accurate.To demonstrate the presence of immune cells in blood samples of patients with ovarian neoplasms. METHODS: In this exploratory ...

Subjective insomnia symptoms and sleep duration are not related to hypothalamic-pituitary-adrenal axis activity in older adults Universiteit Antwerpen

Rian J. G. Peters van Neijenhof, Erik van Duijn, Julia F. Van den Berg, Margot W. M. de Waal, Rosa van der Mast, Hannie C. Comijs
Insomnia symptoms are highly prevalent in depressed older adults. This study investigates the association between hypothalamic-pituitary-adrenal (HPA) axis activity and symptoms of insomnia, respectively, sleep duration among 294 depressed and 123 non-depressed older adults of the Netherlands Study of Depression in Older people (NESDO) study. Insomnia symptoms were defined as clinically relevant when having a score 10 points on the Women's ...

Effect of pH and Comedication on Gastrointestinal Absorption of Posaconazole Monitoring of Intraluminal and Plasma Drug Concentrations KU Leuven

Jeroen Walravens, Joachim Brouwers, Isabel Spriet, Jan Tack, Pieter Annaert, Patrick Augustijns
BACKGROUND AND OBJECTIVE: Posaconazole (Noxafil®) is an extended-spectrum triazole antifungal agent for prevention and treatment of invasive fungal infections. An inadequate dietary intake and abnormal gastric pH levels are common in critically ill patients receiving antifungal treatment with posaconazole, resulting in unpredictable bioavailability and sub-therapeutic plasma concentrations. This study was carried out to elucidate the impact of ...