DNA damage response as a mechanism for radioresistance in head and neck squamous cell carcinoma KU Leuven
The two major carcinogenic routes for developing Head and neck squamous cell carcinoma (HNSCC) are infection with the human papillomavirus (HPV-positive HNSCC) and the overconsumption of alcohol and/or tobacco (HPV-negative HNSCC). Currently, two-thirds of patients with HNSCC are diagnosed in a locally advanced stage, due to lack of symptoms in earlier stages. The current treatment schedule for many patients with locally advanced disease, ...