Publicaties
A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein. Vlaams Instituut voor Biotechnologie
Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein a. Vlaams Instituut voor Biotechnologie
Radiolabeled single-domain antibody fragments for targeted radionuclide therapy of difficult-to-treat cancers Vrije Universiteit Brussel
An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling Universiteit Gent
Single-domain antibodies Vrije Universiteit Brussel
Design and Validation of Site-Specifically Labeled Single-Domain Antibody-Based Tracers for in Vivo Fluorescence Imaging and Image-Guided Surgery Vrije Universiteit Brussel
Near-infrared fluorescence molecular imaging has become an established preclinical technique to investigate molecular processes in vivo and to study novel therapies. Furthermore, fluorescence molecular imaging is gaining significant interest from clinicians as an intra-operative guidance tool. This technique makes use of targeted fluorescent tracers as contrast agents that recognize specific biomarkers expressed at the site of disease. ...
Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: Adjusting the bullet to its target Vrije Universiteit Brussel
CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple Myeloma Vrije Universiteit Brussel Universiteit Gent
Multiple myeloma (MM) is a hematological malignancy characterized by the presence of clonal plasma cells in the bone marrow niche. Despite significant therapeutic advances, MM remains incurable for the majority of patients. Targeted radionuclide therapy (TRNT) has emerged as a promising treatment option to eradicate residual cancer cells. In this study, we developed and characterized single-domain antibodies (sdAbs) against the MM-antigen CS1 ...