Publicaties
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Characterisation of the structure and self-assembly of a small cyclic peptide: an analysis using NMR spectroscopy, diffusion and heteronuclear relaxation measurements Universiteit Gent
Pseudodesmin A, a member of the viscosin group, is a cyclic lipodepsipeptide (CLP) consisting out of an oligopeptide that is cyclised through a lactone bond between its C-terminal carboxyl group and the hydroxyl group of a threonine side chain and a 3-hydroxydecanoic acid moiety bonded to the N-terminal end of the peptide. It is found to self-assemble in apolar organic solvents, which is reminiscent of its expected ability of forming ion pores ...
Implementation of Block Copolymer Based Directed Self-assembly for Advanced Lithography KU Leuven
Optical lithography technology has been one of the key enablers for Moore’s Law for over four decades, allowing semiconductor devices to shrink down by approximately a factor of two every two years. This has brought astounding benefits to the industry, as transistors become cheaper, more powerful and faster as they grow smaller. However, current technology, 193 nm immersion lithography, has reached its fundamental resolution limit and, as such, ...
Influence of chain length of gradient and block copoly(2-oxazoline)s on self-assembly and drug encapsulation Universiteit Gent
Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock ...
Self-assembly of cyclodextrins and their complexes in aqueous solutions KU Leuven
Cyclodextrins (CDs) are enabling pharmaceutical excipients that can be found in numerous pharmaceutical products worldwide. Because of their favorable toxicologic profiles, CDs are often used in toxicologic and phase I assessments of new drug candidates. However, at relatively high concentrations, CDs can spontaneously self-assemble to form visible microparticles in aqueous mediums and formation of such visible particles may cause product ...
Two-Leg Molecular Ladders Formed by Hierarchical Self-Assembly of an Organic Radical KU Leuven
The supramolecular organization of a new polychlorotriphenyl (PTM) radical bearing three long alkyl chains has been studied by scanning tunneling microscopy (STM) at the liquid-solid interface. This radical hierarchically self-assembles on graphite forming head-to-head dimers that organize in rows following an interesting spin-containing two-leg molecular ladder topology, in which the alkyl chains determine the space between the radical rows and ...
Self-assembly of atomically thin chiral copper heterostructures templated by black phosphorus Universiteit Antwerpen
The fabrication of 2D systems for electronic devices is not straightforward, with top-down low-yield methods often employed leading to irregular nanostructures and lower quality devices. Here, a simple and reproducible method to trigger self-assembly of arrays of high aspect-ratio chiral copper heterostructures templated by the structural anisotropy in black phosphorus (BP) nanosheets is presented. Using quantitative atomic resolution ...
How Does Chemisorption Impact Physisorption? Molecular View of Defect Incorporation and Perturbation of Two-Dimensional Self-Assembly KU Leuven
© 2018 American Chemical Society. Chemical and structural defects in otherwise pristine materials can result in either an improved or degraded material performance. Unfortunately, little is known about the role of these defects in complex hierarchical processes, such as self-assembly. Here, the influence of defective surfaces on physisorbed self-assembly occurring at liquid/solid interfaces is investigated. Covalently bound defects on graphite ...
Enhanced Self-Assembly of Metal Oxides and Metal-Organic Frameworks from Precursors with Magnetohydrodynamically Induced Long-Lived Collective Spin States KU Leuven Universiteit Antwerpen
Low energy permanent magnetic fields (0.5T) applied in hydrodynamically turbulent conditions are observed to enhance self-assembly of materials with magnetically frustrated spin systems (spin-glass, spin-ice or spin–liquid). This effect is demonstrated for the crystallization of vanadium oxide nano-scrolls, manganese oxide nano-tubes and HKUST-1 type Cu3(BTC)2.3H2O Metal-Organic Framework. Crystallization of these spin systems involves spin ...
Metal-Ligand Coordination-Induced Self-Assembly of Bolaamphiphiles Bearing Bipyrimidine KU Leuven
A new type of bolaamphiphile bearing bipyrimidine (bpym-8) has been designed and synthesized. The bipyrimidine moiety allows for metal-ligand coordination, thereby influencing the self-assembly of the bolaamphiphile. Before coordination, bpym-8 self-assembles in water to form spherical aggregates. An interesting finding is that the coordination of the Cu(II) ion with bipyrimidine can induce the assembly of bpym-8 to change from spheres to ...