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Secure and efficient application monitoring and replication Universiteit Gent

Stijn Volckaert, Bart Coppens, Alexios Voulimeneas, Andrei Homescu, Per Larsen, Bjorn De Sutter, Michael Franz
Memory corruption vulnerabilities remain a grave threat to systems software written in C/C++. Current best practices dictate compiling programs with exploit mitigations such as stack canaries, address space layout randomization, and control-flow integrity. However, adversaries quickly find ways to circumvent such mitigations, sometimes even before these mitigations are widely deployed. In this paper, we focus on an "orthogonal" defense that ...

Implication and Axiomatization of Functional Constraints on Patterns with an Application to the RDF Data Model Universiteit Hasselt

Jelle HELLINGS, Marc GYSSENS, Jan Paredaens, Yuqing Wu
Akhtar et al. introduced equality-generating constraints and functional constraints as an initial step towards dependency-like integrity constraints for RDF data [1]. Here, we focus on functional constraints. The usefulness of functional constraints is not limited to the RDF data model. Therefore, we study the functional constraints in the more general setting of relations with arbitrary arity. We show that a chase algorithm for functional ...

Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase KU Leuven

Pieter Leyssen, Mathy Froeyen, Johan Neyts, Jan Paeshuyse
The bovine viral diarrhea virus (BVDV), a pestivirus from the family of Flaviviridae is ubiquitous and causes a range of clinical manifestations in livestock, mainly cattle. Two quinolinecarboxamide analogues were identified in a CPE-based screening effort, as selective inhibitors of the in vitro bovine viral diarrhea virus (BVDV) replication, i.e., TO505-6180/CSFCI (average EC50 = 0.07 µM, SD = 0.02 µM, CC50 > 100 µM) and TO502-2403/CSFCII ...

Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity Instituut voor Tropische Geneeskunde Vrije Universiteit Brussel

Marieke Pingen, Annemarie M J Wensing, Katrien Fransen, Annelies De Bel, Dorien de Jong, Andy I M Hoepelman, Emmanouil Magiorkinis, Dimitrios Paraskevis, Maja M Lunar, Mario Poljak, et al.

BACKGROUND: In approximately 10% of newly diagnosed individuals in Europe, HIV-1 variants harboring transmitted drug resistance mutations (TDRM) are detected. For some TDRM it has been shown that they revert to wild type while other mutations persist in the absence of therapy. To understand the mechanisms explaining persistence we investigated the in vivo evolution of frequently transmitted HIV-1 variants and their impact on in vitro ...

Distinctive and complementary roles of E2F transcription factors during plant replication stress responses Universiteit Gent Vlaams Instituut voor Biotechnologie

Maherun Nisa, Thomas Eekhout, Clara Bergis, José Antonio Pedroza-Garcia, Xiaoning He, Christelle Mazubert, Ilse Vercauteren, Toon Cools, Rim Brik-Chaouche, Jeannine Drouin-Wahbi, et al.
Survival of living organisms is fully dependent on their maintenance of genome integrity, being permanently threatened by replication stress in proliferating cells. Although the plant DNA damage response (DDR) regulator SOG1 has been demonstrated to cope with replicative defects, accumulating evidence points to other pathways functioning independently of SOG1. Here, we have studied the role of the Arabidopsis E2FA and EF2B transcription factors, ...

Reverse replication of circular micro grating structures with soft lithography Universiteit Gent

Xiaobing Shang, Jeroen Missinne, Nuria Teigell Beneitez, Michal Jablonski, Jelle De Smet, Pankaj Joshi, Tigran Baghdasaryan, Michael Vervaeke, Hugo Thienpont, Herbert De Smet, et al.
In this work, the reverse replication of circular micro grating structures on glass substrates is implemented using an ultra-violet curable resin and a polydimethylsiloxane (PDMS) mold which has the same structure as the original circular grating master. Two different techniques ("double PDMS replication" and "polymer-PDMS replication") are employed to fabricate those reversed circular micro grating structures. Surface profiling measurements ...