Publicaties
Radiosensitization approaches for HPV-positive and HPV-negative head and neck squamous carcinomas. Vlaams Instituut voor Biotechnologie KU Leuven
Dependence of gold nanoparticle radiosensitization on functionalizing layer thickness KU Leuven
Hypoxic tumor cell radiosensitization through nitric oxide Universiteit Antwerpen
Radiosensitization of non-small cell lung cancer cells by the Plk1 inhibitor volasertib is dependent on the p53 status Universiteit Antwerpen
Hedgehog signaling in prostate cancer: Clinical relevance and its potential as a target for radiosensitization KU Leuven
Barriers in radiobiology Vrije Universiteit Brussel
Hypoxic Radioresistance Vrije Universiteit Brussel
Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological ROS inducers, therefore, has been widely investigated as an approach to enhance aerobic radiosensitization. However, this strategy was overlooked in hypoxic counterpart, one of the most important causes of radiotherapy failure, due to the notion that hypoxic cells ...
The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo KU Leuven
Piperlongumine increases sensitivity of colorectal cancer cells to radiation Vrije Universiteit Brussel
Piperlongumine (PL), naturally synthesized in long pepper, is known to selectively kill tumor cells via perturbation of reactive oxygen species (ROS) homeostasis. ROS are the primary effector molecules of radiation, and increase of ROS production by pharmacological modulation is known to enhance radioresponse. We therefore investigated the radiosensitizing effect of PL in colorectal cancer cells (CT26 and DLD-1) and CT26 tumor-bearing mice. ...