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Approaching Clinical Proteomics: Current State and Future Fields of Application in Cellular Proteomics Universiteit Gent
Abstract: Recent developments in proteomics technology offer new opportunities for clinical applications in hospital or specialized laboratories including the identification of novel biomarkers, monitoring of disease, detecting adverse effects of drugs, and environmental hazards. Advanced spectrometry technologies and the development of new protein array formats have brought these analyses to a standard, which now has the potential to be used in ...
Tissue Based Proteomics and Biomarker Discovery - Multivariate Data Mining Strategies for Mass Spectral Imaging (Weefsel-gebaseerde proteomica en biomerkeranalyse - Multivariate data-analysestrategieën voor massaspectrale beeldvorming) KU Leuven
Het wordt alsmaar duidelijker dat de moleculaire mechanismen die ten gro ndslag liggen aan vele van 's werelds meest invloedrijke ziekten, e en veel grotere complexiteit vertonen dan oorspronkelijk gedacht. Aan di agnostische zijde kent de zoektocht naar ziekte-rapporterende biomerkers in makkelijk toegankelijke vloeistoffen, zoals bloed, slechts gemengd s ucces. De biomerkers in dergelijke vloeistoffen zijn vaak in zodanig lag e concentraties ...
ProteomicsML : an online platform for community-curated data sets and tutorials for machine learning in proteomics Universiteit Gent Vlaams Instituut voor Biotechnologie
Data set acquisition and curation are often the most difficult and time-consuming parts of a machine learning endeavor. This is especially true for proteomics-based liquid chromatography (LC) coupled to mass spectrometry (MS) data sets, due to the high levels of data reduction that occur between raw data and machine learning-ready data. Since predictive proteomics is an emerging field, when predicting peptide behavior in LC-MS setups, each lab ...
Getting a grip on proteomics data: Proteomics Data Collection (ProDaC) Universiteit Gent
In proteomics, rapid developments in instrumentation led to the acquisition of increasingly large data sets. Correspondingly, ProDaC was founded in 2006 as a Coordination Action project within the 6th European Union Framework Programme to support data sharing and community-wide data collection. The objectives of ProDaC were the development of documentation and storage standards, setup of a standardized data submission pipeline and collection of ...
A guide to the Proteomics Identifications Database proteomics data repository Universiteit Gent
Abstract: The Proteomics Identifications Database (PRIDE, www.ebi.ac.uk/pride) is one of the main repositories of MS derived proteomics data. Here, we point out the main functionalities of PRIDE both as a submission repository and as a source for proteomics data. We describe the main features for data retrieval and visualization available through the PRIDE web and BioMart interfaces. We also highlight the mechanism by which tailored queries in ...