Publicaties
MALT Lymphoma as a Model of Chronic Inflammation-Induced Gastric Tumor Development KU Leuven
Prolonged mechanical ventilation worsens sepsis-induced diaphragmatic dysfunction in the rat KU Leuven
Collagen-induced arthritis as an animal model for rheumatoid arthritis: role of IFN-gamma in immunomodulation by mesenchymal stem cells and in extra-articular manifestations. KU Leuven
Exploring non-invasive signatures of kidney allograft pathology KU Leuven
Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection KU Leuven
Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models Vrije Universiteit Brussel Universiteit Gent
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. HCC typically develops on a background of chronic inflammation and fibrosis with tumor associated macrophages (TAMs) playing an important role in chronic inflammation-induced HCC and progression. However, the liver harbors unique macrophages, resident liver Kupffer cells (KCs) and monocyte-derived macrophages (Mo-Mφ), and their contribution to HCC ...
The CD26/DPP4-inhibitor vildagliptin suppresses lung cancer growth via macrophage-mediated NK cell activity Universiteit Antwerpen
Targeted radionuclide therapy with low and high-dose Lutetium-177 labeled single domain antibodies induces distinct immune signatures in a mouse melanoma model Vrije Universiteit Brussel
Targeted radionuclide therapy (TRT) using probes labeled with Lutetium-177 represents a new and growing type of cancer therapy. We studied immunological changes in response to TRT with Lutetium-177 labeled anti-human CD20 camelid single domain antibodies (sdAbs) in a B16-melanoma model transfected to express human CD20, the target antigen, and ovalbumin, a surrogate tumor antigen. High-dose TRT induced melanoma cell death, calreticulin ...