ChOLLATERAL: Genereren van een netwerk van ongunstige uitkomstroutes op cholestatische leverbeschadiging voor op mechanismen gebaseerde in-vitrotesten van chemicaliën. Vrije Universiteit Brussel
Cholestasis refers to toxic bile acid accumulation mainly in the liver and can be induced by many chemical compounds, in particular drugs. At present, drug-induced cholestatic injury (DICI) is poorly predictable and is an important reason for drug withdrawal from the market as well as a major clinical issue. A solution lies in better understanding the mechanisms of DICI. A pragmatic tool to visually and rationally capture the ...