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Dependence of treatment planning accuracy in peptide receptor radionuclide therapy on the sampling schedule KU Leuven
BACKGROUND: Peptide receptor radionuclide therapy (PRRT) plays an important role in the treatment of neuroendocrine tumors (NET). Pre-therapeutic dosimetry using the area under the measured time-activity curve (AUC) is important. The sampling schedule for this dosimetry determines the accuracy and reliability of the obtained AUC. The aim of this study was to investigate the effect of reduced number of measurement points (i.e., gamma camera image ...
Potential sealing and repair of humanFMdefects after trauma with peptide amphiphiles and Cx43 antisense KU Leuven
OBJECTIVE: We examined whether peptide amphiphiles functionalised with adhesive, migratory or regenerative sequences could be combined with amniotic fluid (AF) to form plugs that repair fetal membrane (FM) defects after trauma and co-culture with connexin 43 (Cx43) antisense. METHODS: We assessed interactions between peptide amphiphiles and AF and examined the plugs in FM defects after trauma and co-culture with the Cx43antisense. RESULTS: ...
The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels KU Leuven Universiteit Gent
One of the most potent insecticidal venom peptides described to date is Aps III from the venom of the trapdoor spider Apomastus schlingeri. Aps III is highly neurotoxic to lepidopteran crop pests, making it a promising candidate for bioinsecticide development. However, its disulfide-connectivity, three-dimensional structure, and mode of action have not been determined. Here we show that recombinant Aps III (rAps III) is an atypical knottin ...
The 1,3-diyne linker as a rigid 'i,i+7' staple for α-helix stabilization : stereochemistry at work Universiteit Gent
Short alphahelical peptide sequences were stabilized through Glaser-Hay couplings of propargylated l- and/or d-serine residues at positions i and i+7. NMR analysis confirmed a full stabilization of the helical structure when a d-Ser (i), l-Ser (i+7) combination was applied. In case two l-Ser residues were involved in the cyclization, the helical conformation is disrupted outside the peptide's macrocycle.
Design of cell-permeable nanoneedles as HIV-1 integrase inhibitors KU Leuven
DESIGN OF CELL-PERMEABLE NANONEEDLES AS HIV-1 INTEGRASE INHIBITORS Ya-Qiu Long*,†, Shao-Xu Huang†, ‡, Zahrah Zawahir§,‡, Huiyuan Li†, Tino W. Sanchez§, Ying Zhi†, Frauke Christ¶, Zeger Debyser¶, Nouri Neamati*,§ †State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; §Department of Pharmacology and ...
Targeted Nanobody-Based Molecular Tracers for Nuclear Imaging and Image-Guided Surgery Vrije Universiteit Brussel
Molecular imaging is paving the way towards noninvasive detection, staging, and treatment follow-up of diseases such as cancer and inflammation-related conditions. Monoclonal antibodies have long been one of the staples of molecular imaging tracer design, although their long blood circulation and high nonspecific background limits their applicability. Nanobodies, unique antibody-binding fragments derived from camelid heavy-chain antibodies, have ...
What is gluten? KU Leuven
Gluten is the main storage protein of wheat grains. Gluten is a complex mixture of hundreds of related but distinct proteins, mainly gliadin and glutenin. Similar storage proteins exist as secalin in rye, hordein in barley, and avenins in oats and are collectively referred to as "gluten." The objective was to discuss the biochemical and functional properties of the gluten proteins, including structure, sources, and dietary intakes. Literature ...
CONSTANd : a normalization method for isobaric labeled spectra by constrained optimization Universiteit Hasselt Universiteit Antwerpen
In quantitative proteomics applications, the use of isobaric labels is a very popular concept as they allow for multiplexing, such that peptides from multiple biological samples are quantified simultaneously in one mass spectrometry experiment. Although this multiplexing allows that peptide intensities are affected by the same amount of instrument variability, systematic effects during sample preparation can also introduce a bias in the ...