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Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci Universiteit Antwerpen

Kerstin U. Ludwig, Elisabeth Mangold, Stefan Herms, Bettina Blaumeiser, et al.
We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date. We confirmed associations with all previously identified loci and identified six additional susceptibility regions (1p36, 2p21, 3p11.1, 8q21.3, 13q31.1 and 15q22). Analysis of phenotypic variability identified the first specific genetic risk factor for NSCLP ...

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate Universiteit Antwerpen

Elisabeth Mangold, Kerstin U. Ludwig, Stefanie Birnbaum, Bettina Blaumeiser, Markus Nöthen, et al.
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 × 10−8, relative risk in homozygotes = 1.84, 95% CI 1.342.53) and 10q25.3 (rs7078160, combined P = 1.92 × 10−8, relative risk in homozygotes = ...

Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene KU Leuven

Joris Vermeesch, Koenraad Devriendt, Greet Hens, Carine Carels
Non-syndromic cleft lip with or without cleft palate (nsCL/P) ranks among the most common human congenital malformations, and has a multifactorial background in which both exogenous and genetic risk factors act in concert. The present report describes a genome-wide association study (GWAS) involving a total of 285 nsCL/P patients and 1212 controls from the Netherlands and Belgium. Twenty of the 40 previously reported nsC/LP susceptibility loci ...

Sunitinib Malate plus Lomustine for Patients with Temozolomide-refractory Recurrent Anaplastic or Low-grade Glioma Vrije Universiteit Brussel

Johnny Duerinck, Stephanie Du Four, Wilhelm Sander, Anne-Marie Van Binst, Hendrik Everaert, Alex Michotte, Peter Hau, Bart Neyns

Tyrosine kinase signaling through the vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor- α (PDGFR-α) and KIT cell surface receptors mediates neo-angiogenesis and contributes to cancer cell survival in recurrent anaplastic and low-grade glioma. Thirteen patients with temozolomide-refractory recurrent anaplastic or low-grade glioma were treated with sunitinib malate, a small-molecule tyrosine kinase ...

Identification of an unknown spatial load distribution in a vibrating beam or plate from the final state Universiteit Gent

Karel Van Bockstal
The theoretical and numerical determination of a space-dependent load distribution in a simply supported non-homogeneous Euler-Bernoulli beam and Kirchhoff-Love plate is investigated. The uniqueness of a solution to this inverse source problem is proved, whilst counter examples are constructed to discuss the conditions under which uniqueness holds. A convergent and stable iterative algorithm is proposed for the recovery of the unknown load ...

Cytoreductive nephrectomy and exposure to sunitinib : a post hoc analysis of the immediate surgery or surgery after sunitinib malate in treating patients with metastatic kidney cancer (SURTIME) trial Universiteit Gent

Yasmin AbuU+2010Ghanem, Johannes V. Thienen, Christian Blank, Maureen J. B. Aarts, Michael Jewett, Igle Jan Jong, JeanU+2010Baptiste Lattouf, Harm H. E. Melick, Lori Wood, Peter Mulders, et al.
Objective To analyse if exposure to sunitinib in the Immediate Surgery or Surgery After Sunitinib Malate in Treating Patients With Metastatic Kidney Cancer (SURTIME) trial, which investigated opposite sequences of cytoreductive nephrectomy (CN) and systemic therapy, is associated with the overall survival (OS) benefit observed in the deferred CN arm. Patients and Methods A post hoc analysis of SURTIME trial data. Variables analysed included ...

Self-Esteem and Oral Health-Related Quality of Life within a Cleft Lip and/or Palate Population: A Prospective Cohort Study Universiteit Hasselt KU Leuven

A Aleksieva, G Begnoni, A Verdonck, Annouschka LAENEN, G Willems, MC de Llano-Perula
(1) Objective: To investigate the oral health-related quality of life (OHRQoL) and self-esteem (SE) of a population with cleft lip and/or palate (CLP) and to compare it with a non-affected control cohort. (2) Materials and methods: This study comprised 91 CLP patients and a control group of 790 individuals, seeking orthodontic treatment. OHRQoL and SE were assessed by the Child's Perception Questionnaire (CPQ) and the Dutch adaptation of the ...

Assessment of craniofacial maturation in preadolescents with cleft lip and/or palate using the cervical vertebral maturation method Universiteit Gent KU Leuven

Laurent Thierens, Laura Manalili, Noëmi De Roo, An Verdonck, Maria Cadenas De Llano-Pérula, Guy De Pauw
Objectives Aberrant growth of the maxillomandibular complex in patients with cleft lip and/or palate (CL/P) can be managed with dentofacial orthopaedics. However, no consensus has been reached regarding timing and evolution of the maturational stages. Therefore, the aim of this study is to determine if patients with CL/P have an increased risk for delayed craniofacial maturation. Materials and methods A sample of 246 cleft patients and 210 ...

"Flip-over flap" in two-stage cleft palate repair Vrije Universiteit Brussel

Maurice Y Mommaerts, Karsten Kh Gundlach, Ana Tache

PURPOSE: This study served to evaluate a two-stage concept in cleft palate repair, including key use of a triangular hinge ("flip-over") flap, in order to prevent palatal fistulae. It uses data from a prospective registry established in 1991.

MATERIALS AND METHODS: The concept entails Furlow soft palate repair (at 1 year of age) and hard palate closure (at 4 years) by a three-pronged approach [paring of the edges with or without ...