Publicaties
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Efficient delivery of intact phosphodiester oligonucleotides by poly-U+03B2-amino esters Universiteit Gent
Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic Selection KU Leuven
The chemical diversification and enzymatic proliferation of artificial genetic polymers (xeno nucleic acids, XNAs) is an intriguing avenue of research, especially in view of potential applications in synthetic biology. One of the main goals in this area is to achieve the genetic reprogramming of novel microorganisms through the development of both chemical and biological tools. For this purpose, oligonucleotide analogues, showing good ...
Lipoplexes to deliver oligonucleotides in gram-positive and gram-negative bacteria : towards treatment of blood infections Universiteit Gent
Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models Universiteit Gent
A Compositional Model to Predict the Aggregated Isotope Distribution for Average DNA and RNA Oligonucleotides Universiteit Hasselt
Structural modifications of DNA and RNA molecules play a pivotal role in epigenetic and posttranscriptional regulation. To characterise these modifications, more and more MS and MS/MS- based tools for the analysis of nucleic acids are being developed. To identify an oligonucleotide in a mass spectrum, it is useful to compare the obtained isotope pattern of the molecule of interest to the one that is theoretically expected based on its elemental ...