Publicaties

Background: Cases of cefepime neurotoxicity have been Sporadically reported in patients with renal failure. The neurotoxicity of cefepime might be underestimated and the frequency of its neurotoxic effects may be insufficiently recognized.
Methods: We retrospectively reviewed the files of patients with renal failure who were treated with cefepime and who developed neurological complications.

Results: All 8 patients developed ...

Currently, neurotoxicity testing defined by OECD and FDA is based solely on in vivo experiments, using large numbers of animals, being expensive, time-consuming and unsuitable for screening numerous chemicals. The great demand for thousands of chemicals yet to be evaluated, urges the development of alternative test methods which are cheaper, faster and highly predictive for developmental neurotoxicity. In this study, we developed a new method to ...

The developmental neurotoxic potential of the majority of environmental chemicals and drugs is currently undetermined. Specific in vivo studies provide useful data for hazard assessment but are not amenable to screen thousands of untested compounds. In this study, methods which use zebrafish embryos, eleutheroembryos and larvae as model organisms, were proposed as alternatives for developmental neurotoxicity (DNT) testing. The evaluation of ...

Since the reformulation of the amyloid cascade hypothesis to focus on oligomeric aggregates of
amyloid beta as the prime toxic species causing Alzheimer's disease, many researchers refocused on
detecting a specifi c molecular assembly of defi ned size that is the main trigger of Alzheimer's disease. The result has been the identifi cation of a host of molecular assemblies containing from two up to a hundred molecules of the amyloid ...

The amyloid peptides Ab40 and Ab42 of Alzheimer's disease are thought to contribute differentially to the disease process. Although Ab42 seems more pathogenic than Ab40, the reason for this is not well understood. We show here that small alterations in the Ab42:Ab40 ratio dramatically affect the biophysical and biological properties of the Ab mixtures reflected in their aggregation kinetics, the morphology of the resulting amyloid fibrils and ...

We describe a patient with severe New Delhi metallo-?-lactamase-1 Escherichia coli infection who developed convulsions rapidly followed by acute respiratory muscle weakness and apnea while receiving intravenous colistin. Toxic levels of colistin were rapidly removed by hemofiltration and, more specifically, by hemoadsorption.

The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite ...

Background Occupational exposure to solvents may lead to neurotoxicity and sleep disturbances. We aimed to investigate the association of occupational exposure to petroleum-derived hydrocarbons with neurotoxicity and sleep disturbance symptoms. Methods We included male workers handling/distributing petroleum products (exposed, n=250) and electricians (non-exposed, n=250) from two companies in Tlemcen (Algeria). Neurotoxicity was evaluated with ...