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Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method Instituut voor Tropische Geneeskunde
Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of monitoring strategies on timing of failure detection.
We identified studies reporting microbiological response to MDR-TB treatment and solicited individual patient data from authors. Frailty survival models were used to ...