Projecten
Diepe eencellige fenotypering om de leidende principes en mechanismen van de subcellulaire organisatie van bacteriële replicatie te identificeren KU Leuven
Modern metagenomics has opened our eyes to the immense bacterial diversity that exists both among and within us. Despite this diversity, all bacteria share the basic challenge of organizing the various processes that ensure their faithful replication. All bacterial cells need to metabolize nutrients, generate building blocks, maintain their shape and size, replicate and segregate their chromosomes, synthesize cell walls and membranes, and ...
Protein-based next generation electronics PRINGLE Vlaams Instituut voor Biotechnologie
Het blootleggen van enterische GLIA-macrofaag communicatie in de intestinale homeostase en ontsteking. KU Leuven
Uncovering Enteric GLIA-MACrophage communication in the intestinal homeostasis and inflammation. The enteric nervous system (ENS) is a network of neurons and enteric glial cells (EGCs) organized in ganglia essential to control gastrointestinal physiology. Although EGCs have historically been described as supporting cells for enteric neurons, recent data from my previous work and from my host group demonstrated that enteric glia is ...
Microbiële gemeenschappen in biomedische en omgevingsgebieden en systeembiologie KU Leuven
"The main goal of the proposed project is to strengthen scientific excellence and innovation capacity at Charles University and its Biotechnology and Biomedicine Center (CUNI-BIOCEV) via collaboration with Catholic University of Leuven (KUL), European Molecular Biology Laboratory (EMBL), and University Paris Diderot-Institute Jacques Monod (UPDiderot-IJM) in the field of high throughput molecular profiling of biological systems that will ...
Synthese van spirooxindolen en indolen-geneesmiddelen met metaal-organische frameworks KU Leuven
SINMOF is a pioneering and structured effort to comprehensively address the introduction of different immobilised isolated catalytic active sites in solid hybrid materials to overcome the metal losses occurring with state-of-the-art homogeneous catalysts employed in the pharmaceutical industry. The convenient use of hybrid metal-organic framework materials (MOFs) respect to traditional state-of-the-art porous solid materials is due to (a) ...
Methodological developments for time-resolved single particle cryo-EM Vlaams Instituut voor Biotechnologie
Microben in de stad: een metagenomics truit-gebaseerde analyse van microbiële metagemeenschapsstructuur langs urbanisatiegradiënten. KU Leuven
Human induced environmental gradients have a strong effect on biodiversity and ecosystem functioning. Despite the valuable ecosystem services (such as biogeochemical cycling and xenobiotic degradation) provided by microbial communities, environmental conservation policies usually neglect microbial diversity. This can be in part attributed to our poor understanding of microbial community responses to anthropogenic influences in natural ...
Organoïde technologieën voor ziektemodellering, ontdekking van geneesmiddelen en ontwikkeling voor zeldzame ziekten KU Leuven
The vast majority of rare diseases are characterized by genetic origin, often severe in pathology and with limited or no treatment options. This also includes the paediatric disorders cystic fibrosis (CF) and cystinosis. Both diseases usually manifest in the first year of life. In recent year, great progress has been made in CF research allowing a swift transfer of novel drugs from bench to bedside. This is fueled by the application of ...
EBRAINS 2.0: een onderzoeksinfrastructuur ter bevordering van de neurowetenschappen en de gezondheid van de hersenen KU Leuven
EBRAINS is a collaborative European Research Infrastructure designed to advance and accelerate progress in neuroscience and brain health. This innovative infrastructure, a legacy of the Human Brain Project (HBP), is an ecosystem where researchers, clinicians and experts from various disciplines converge to explore and analyze brain complexity – from molecular and cellular levels to the functioning of the entire organ. Therefore, the project ...