When under pressure, get closer: PERKing up membrane contact sites during ER stress KU Leuven
The endoplasmic reticulum (ER) is the main hub of cellular Ca(2+)signalling and protein synthesis and folding. The ER moreover is the central player in the formation of contact sites with other organelles and structures, including mitochondria, plasma membrane (PM) and endosomes. The most studied of these, the ER-mitochondria contact sites, are crucial regulators of cellular Ca(2+)homoeostasis, metabolism and cell death signalling. Protein ...