Publicaties
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Predictors of lung recurrence and disease-specific mortality after pulmonary metastasectomy for soft tissue sarcoma Vrije Universiteit Brussel
BACKGROUND: We identified prognostic factors in a 30-year series of STS treated at a single Institution, using an advanced statistical approach.
METHODS: From June 1988 to July 2019, 164 patients were referred to Rizzoli Orthopedic Hospital, Bologna, Italy) for STS lung metastasectomy (LMTS). The endpoints were lung metastasis recurrence (LMR) and lung metastasis-specific mortality (LMSM). The analysis included directed acyclic graphs, ...
Generation of lung epithelial-like tissue from human embryonic stem cells Vrije Universiteit Brussel
BACKGROUND: Human embryonic stem cells (hESC) have the capacity to differentiate in vivo and in vitro into cells from all three germ lineages. The aim of the present study was an investigation on the effect of specific culture conditions on differentiation of hESC into lung epithelial cells. METHODS: Undifferentiated hESC were grown on a porous membrane in a differentiation medium for four days followed by culture for further 25 days in ...
In vivo electrical bioimpedance characterization of human lung tissue during the bronchoscopy procedure. A feasibility study Vrije Universiteit Brussel
Lung biopsies form the basis for the diagnosis of lung cancer. However, in a significant number of cases bronchoscopic lung biopsies fail to provide useful information, especially in diffuse lung disease, so more aggressive procedures are required. Success could be improved using a guided electronic biopsy based on multisine electrical impedance spectroscopy (EIS), a technique which is evaluated in this paper. The theoretical basis of the ...
Minimally invasive in vivo human lung tissue bioimpedance measurements during the bronchoscopy procedure Vrije Universiteit Brussel
Lung biopsies are the basis for the diagnosis of lung cancer. Bronchoscopic lung biopsies fail to provide useful information in a significant number of cases, especially in diffuse lung disease, so more aggressive procedures are required. Success could be improved by using an electronic biopsy based on electrical bioimpedance (EBI) measurements. EBI can be obtained from several locations on the lung parenchyma ...
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis KU Leuven
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered by the lack of organotypic models and analytical techniques. In this work, we coupled ex vivo cytokine and drug perturbations of human precision-cut lung slices (hPCLS) with single-cell RNA sequencing and induced a multilineage circuit of fibrogenic cell states in ...
Tissue and Plasma EGFR Mutation Analysis in the FLAURA Trial: Osimertinib versus Comparator EGFR Tyrosine Kinase Inhibitor as First-Line Treatment in Patients with EGFR-Mutated Advanced Non-Small Cell Lung Cancer KU Leuven
PURPOSE: To assess the utility of the cobas EGFR Mutation Test, with tissue and plasma, for first-line osimertinib therapy for patients with EGFR-mutated (EGFRm; Ex19del and/or L858R) advanced or metastatic non-small cell lung cancer (NSCLC) from the FLAURA study (NCT02296125). EXPERIMENTAL DESIGN: Tumor tissue EGFRm status was determined at screening using the central cobas tissue test or a local tissue test. Baseline circulating tumor (ct)DNA ...
Mechanic's hands in a woman with undifferentiated connective tissue disease and interstitial lung disease - anti-PL7 positive antisynthetase syndrome: a case report KU Leuven
Interstitial lung disease can be idiopathic or occur in the setting of connective tissue diseases. In the latter case it requires a different treatment approach with a better prognosis. Interstitial lung disease can precede the onset of typical connective tissue disease features by many years, and therefore meticulous multidisciplinary follow-up is crucial. This case highlights the diagnostic challenge and the need for intensified attention for ...