Publicaties
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LncRNA profiling in T-cell acute lymphoblastic leukemia predicts a functional connection between lncRNAs and the major T-ALL genetic subgroups Universiteit Gent
Exploring lncRNAs in cancer : tools for discovery and characterization of cancer associated lncRNAs Universiteit Gent
Differential expression of lncRNAs during the HIV replication cycle : an underestimated layer in the HIV-host interplay Universiteit Gent
LncRNAs as novel players in neuroblastoma tumor biology Universiteit Gent
In neuroblastoma, several protein coding genes are established as key players in the tumorigenesis and pathogenesis, such as ALK, MYCN and PHOX2B. These proteins regulate a plethora of other genes, however, little is known about their non-coding targets. Based on the combination of RNA sequencing data of 497 primary tumor samples and model systems for MYCN, ALK and PHOX2B, we could demonstrate that each of these key neuroblastoma genes regulate ...
LncRNAs in Cancer: From garbage to Junk KU Leuven
Sequencing-based transcriptomics has significantly redefined the concept of genome complexity, leading to the identification of thousands of lncRNA genes identification of thousands of lncRNA genes whose products possess transcriptional and/or post-transcriptional regulatory functions that help to shape cell functionality and fate. Indeed, it is well-established now that lncRNAs play a key role in the regulation of gene expression through ...
N6-Methyladenosine (m6A)-Related lncRNAs Are Potential Signatures for Predicting Prognosis and Immune Response in Lung Squamous Cell Carcinoma KU Leuven
BACKGROUND: Despite increasing understanding of m6A-related lncRNAs in lung cancer, the role of m6A-related lncRNAs in the prognosis and treatment of lung squamous cell carcinoma is poorly understood to date. Thus, the current study aims to elucidate its role and build a model to predict the prognosis of LUSC patients. MATERIALS AND METHODS: The data of the current study were accessed from the TCGA database. Pearson correlation analysis was ...
Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks Vrije Universiteit Brussel
Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this study, we investigated the function of β ...
Identification of lncRNAs involved in neuronal differentiation and intellectual disability Universiteit Gent
Recent studies have assigned important functions to lncRNAs in gene regulation and protein interactions. Since many of these lncRNAs emerged recently during vertebrate and primate evolution, a crucial role in the human brain is anticipated. Here, we aimed at identifying candidate lncRNAs associated with neuronal development and intellectual disability (ID). To do this, we combined genomic annotations (i.e. LNCipedia database) with functional ...