Publicaties
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General and mild Ni-0-catalyzed alpha-arylation of ketones using aryl chlorides Universiteit Gent
A general methodology for the alpha-arylation of ketones using a nickel catalyst has been developed. The new well-defined [Ni(IPr*)(cin) Cl] (1c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. This cinnamyl-based Ni-N-heterocyclic carbene (NHC) complex has demonstrated a different behaviour to ...
Role of ketones, ketogenic diets and intermittent fasting in ICU KU Leuven
PURPOSE OF REVIEW: To summarize the clinical evidence for beneficial effects of ketones, ketogenic diets and intermittent fasting in critical illness, and to review potential mechanisms behind such effects. RECENT FINDINGS: Recent evidence demonstrates that activation of a metabolic fasting response may be beneficial to recover from critical insults. Potential protective mechanisms are, among others, activation of ketogenesis and of damage ...
Light-stable silver N-heterocyclic carbene catalysts for the alkynylation of ketones in air Universiteit Gent
Highly efficient and eco-friendly gold-catalyzed synthesis of homoallylic ketones Universiteit Gent
We report a new catalytic protocol for the synthesis of gamma,delta-unsaturated carbonyl units from simple starting materials, allylic alcohols and alkynes, via a hydroxalkoxylation/Claisen rearrangement sequence. This new process is more efficient (higher TON and TOF) and more eco-friendly (increased mass efficiency) than the previous state-of-the-art technique. In addition, this method tolerates both terminal and internal alkynes. Moreover, ...