Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice KU Leuven
AbstractObjective: It is believed that an organism remains normoglycemic despite an increase in the ss-cell mass due to decreased insulin production by ss-cells on a per cell basis. However, some transgenic mouse models with ss-cell hyperplasia suggest that insulin production remains excessive and that normoglycemia is maintained by insulin resistance. Methods: Here, we investigated the effect of an increased ss-cell mass on glycemia and insulin ...