Een compleet model voor eiwit aggregatie en zijn toepassing op het ontwerp van monoclonale antilichamen en peptides voor doelgerichte aggregatie KU Leuven
Protein aggregation, the process by which polypeptide molecules form larger order homotypic interactions, plays a major role in both healthy and and disease-associated physiology. Functional amyloids for example, have been discovered in all kingdoms of life, including human. In sharp contrast, depositions of protein aggregates in patient’s tissues are the clinical hallmark of over 30 human diseases and unwanted protein aggregation is an ...