Polyclonal B-cell activation in human African tryponosomiasis (HAT): impact on acquired immunity and on rapid diagnostic tests. Instituut voor Tropische Geneeskunde
Mouse-models help to understand host-pathogen immune interactions and serve as model for vaccine development in human African trypanosomiasis (HAT) but their validity for what happens in man remains largely unknown. A better understanding of the immune deregulation observed in HAT, especially related to the B-cell compartment, is therefore needed and may have implications on clinical management and control of other infections as ...