Projecten
Targeting the metabolism-immune system connections in cancer - META-CAN - Marie Sklodowska-Curie actions (ITN) Vlaams Instituut voor Biotechnologie
Door blootstelling geïnduceerde immuuneffecten in kaart brengen: het exposoom en het immunoom verbinden KU Leuven
Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed.
The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, ...
Betere controle en behandeling van immuun-gemedieerde ziekten door het universum van door micro-omgeving opgelegde weefselsignaturen en hun correlaten in vloeibare biopten te verkennen KU Leuven
mmune-mediated diseases (IMIDs) are an increasing medical burden in industrialized countries worldwide. IMIDs are characterized by an enormous heterogeneity with regard to disease outcome and response to targeted therapies, which currently cannot be adequately anticipated to tailor individual patient management. Hence, mechanistic understanding of this heterogeneity and biomarkers predictive for disease control and therapy response over time ...
Cholinergische modulatie van immuunhomeostase: nieuwe behandelingsmogelijkheden. KU Leuven
In the gastrointestinal tract, the balance between activation of the mucosal immune system and tolerance should be tightly regulated to maintain immune homeostasis to prevent chronic inflammation and tissue damage. Recently, the new concept was introduced that the vagus nerve plays an important role in modulating immune homeostasis as part of a so-called inflammatory reflex. We provided evidence for this concept in the gastrointestinal tract ...
Immunome project consortium for AutoInflammatory Disorders KU Leuven
Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve ...
IMI 2 project: 3TR: Taxonomy, treatment, targets and remission Universiteit Hasselt
Meervoudige manifestaties van genetische en niet-genetische factoren in Multiple Sclerosis ontrafelden met een multi-omics benadering om gepersonaliseerde geneeskunde te versnellen KU Leuven
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.
MultipleMS will therefore develop, validate, and exploit ...
Versterking van de onderzoeksruimte van levering van nucleïnezuur nabootsers (NAMS) in bacteriën om de antibioticakrisis te bestrijden Universiteit Gent
DelNAM richt zich op het versterken van de onderzoeksruimte van levering van nucleïnezuurnabootsers (NAMS) in bacteriën om de antibioticakrisis te bestrijden. Dit wordt bereikt door de Faculty of Engineering van de Universiteit van Porto (FEUP) samen te brengen met uitstekende EU-instellingen met een hoge expertise op het gebied van de ontwikkeling van NAM's en nanodeleverstrategieën. DelNAM zal de ontwikkeling mogelijk maken van een ...
Biomerkers van niertransplantaatletsels bij ontvangers van nierallotransplantaten. KU Leuven
In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient treatment, quality of life and long-term graft ...