Stem-cell-derived human microglia transplanted into mouse brain to study human disease KU Leuven Universiteit Antwerpen Vlaams Instituut voor Biotechnologie
Microglia are critically involved in complex neurological disorders with a strong genetic component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia. Although mouse microglia can recapitulate aspects of human microglia physiology, they do not fully capture the human genetic aspects of disease and do not reproduce all human cell states. Primary cultures of human microglia or microglia derived from human induced ...