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Design of a Q-learning-based client quality selection algorithm for HTTP adaptive video streaming Universiteit Gent
QoE optimization through in-network quality adaptation for HTTP adaptive streaming Universiteit Gent
First report of a de novo iTTP episode associated with an mRNA-based anti-COVID-19 vaccination Universiteit Antwerpen KU Leuven
Thrombotic thrombocytopenic purpura (TTP) is a rare but potentially life-threatening thrombotic microangiopathy, characterized by disseminated thrombus formation in the microvasculature, causing severe organ failure. Immune-mediated TTP (iTTP) is occasionally described after vaccination, especially against viral agents. We report a case of a 38-year-old woman with a de novo iTTP after exposure to the mRNA-based anti-coronavirus disease 2019 ...
Anti-cysteine/spacer antibodies that open ADAMTS13 are a common feature in iTTP KU Leuven
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is caused by an autoantibody-mediated deficiency in ADAMTS13. In healthy individuals, ADAMTS13 has a folded conformation in which the central spacer (S) domain interacts with the C-terminal CUB domains. We recently showed that ADAMTS13 adopts an open conformation in iTTP and that patient immunoglobulin G antibodies (IgGs) can open ADAMTS13. Anti-ADAMTS13 autoantibodies in patients with ...
Knocking on IPs: Identifying HTTPS Websites for Zero-Rated Traffic Universiteit Hasselt
Zero-rating is a technique where internet service providers (ISPs) allow consumers to utilize a specific website without charging their internet data plan. Implementing zero-rating requires an accurate website identification method that is also efficient and reliable to be applied on live network traffic. In this paper, we examine existing website identification methods with the objective of applying zero-rating. Furthermore, we demonstrate the ...
Realistically Fingerprinting Social Media Webpages in HTTPS Traffic Universiteit Hasselt
In webpage fingerprinting (WPF), an adversary attempts to identify webpages in encrypted network traffic. Identifying social media webpages however is a challenging task, due to the similarity and dynamic nature of such pages. Existing webpage fingerprinting attacks often have unrealistic assumptions regarding the capability of government agencies or knowledge of the criminal’s environment, which renders these attacks ineffective when applied to ...
N-glycan-mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP KU Leuven
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder caused by the development of autoantibodies targeting different domains of ADAMTS13. Profiling studies have shown that residues R568, F592, R660, Y661, and Y665 within exosite-3 of the spacer domain provide an immunodominant region of ADAMTS13 for pathogenic autoantibodies that develop in patients with iTTP. Modification of these 5 core residues with the goal of ...
Deletion of platelet CLEC-2 decreases GPIba-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP KU Leuven
Microvascular thrombosis in patients with thrombotic thrombocytopenic purpura (TTP) is initiated by GPIbα-mediated platelet binding to von Willebrand factor (VWF). Binding of VWF to GPIbα causes activation of the platelet surface integrin αIIbβ3. However, the mechanism of GPIbα-initiated activation of αIIbβ3 and its clinical importance for microvascular thrombosis remain elusive. Deletion of platelet C-type lectin-like receptor 2 (CLEC-2) did ...