Loss of system xc- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility Vrije Universiteit Brussel
System xc- exchanges intracellular glutamate (Glu) for extracellular cystine, giving it a role in intracellular glutathione synthesis and non-vesicular Glu release. We report that mice lacking the specific subunit of system xc- (xCT-/-) do not have lower hippocampal glutathione content or increased oxidative stress, nor exacerbated spatial reference memory deficits with ageing, indicating that loss of system xc- does not induce oxidative stress ...