Skeletal control of hematopoiesis: Impact of the stromal-vascular bone marrow niche in the support of fetal and adult hematopoiesis KU Leuven
Bone is not only crucial for allowing movement, providing support and protection for vital organs and maintaining mineral homeostasis, but the skeleton also represents the prime site for blood cell production or hematopoiesis. To ensure constant blood cell levels under homeostatic conditions and rapid responses to emergencies or injuries, the balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) needs to be tightly ...