Publicaties
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Unveiling the intricacies of gene delivery Vrije Universiteit Brussel
In order to unlock the full potential of gene therapy, understanding the cellular uptake mechanisms and choosing the most suitable delivery vehicle are crucially important. In the paper by Del Toro Runzer and colleagues recently published in Molecular Therapy – Nucleic Acids, the roles of the cellular uptake
mechanism, microenvironment, and cell type on the delivery of genetic materials
were extensively investigated (Figure 1).1 ...
mechanism, microenvironment, and cell type on the delivery of genetic materials
were extensively investigated (Figure 1).1 ...
Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy Universiteit Gent
Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery Universiteit Gent
Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers Universiteit Gent
Layer-by-Layer technique as a versatile tool for gene delivery applications Vrije Universiteit Brussel
Introduction: Gene therapy is a breakthrough medical field which focuses on the therapeutic delivery of recombinant nucleic acids in order to treat or prevent a broad spectrum of diseases. However, a number of important obstacles remain before its wide introduction into clinical practice can be envisaged. One of the biggest bottlenecks is the lack of efficient and safe delivery technologies, particularly, for in vivo distribution. Above and ...