Publicaties
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Efficacy and safety of a bovine-associated Staphylococcus aureus phage cocktail in a murine model of mastitis Universiteit Gent
Prevalence of and factors associated with lactational mastitis in eastern and southern Africa: an exploratory analysis of community-based household surveys Instituut voor Tropische Geneeskunde
Background Lactational mastitis is an extremely painful and distressing inflammation of the breast, which can seriously disrupt breastfeeding. Most of the evidence on the frequency of this condition and its risk factors is from high-income countries. Thus, there is a crucial need for more information on lactational mastitis and its associated factors in Sub-Saharan Africa (SSA). Methods We used data from representative, community-based ...
Pathogen-group specific association between CXCR1 polymorphisms and subclinical mastitis in dairy heifers KU Leuven Universiteit Gent
The chemokine (C-X-C motif) receptor 1 (CXCR1) gene encodes the homonymous receptor for interleukin 8 (IL8) on polymorphonuclear neutrophilic leucocytes (PMNL). Binding causes migration from blood to milk, activation and prolonged survival of PMNL, a crucial process in the innate immune defence of the bovine mammary gland against invading mastitis-causing pathogens. The main objective of this study was to screen the entire coding region of the ...
Development of the PlyC endolysin as a bovine mastitis therapeutic for lactating dairy cows Universiteit Gent
Bovine mastitis, defined as an inflammation of the cow’s mammary gland, is the most common and economically significant disease affecting dairy cattle and the leading cause of antimicrobial use on dairy farms. Streptococcus uberis is currently the most prevalent Gram-positive pathogen causing this infection. Recent growing concerns among consumers regarding the potential for antimicrobial resistance have led to the examination of alternative ...
The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle. KU Leuven Universiteit Gent
Mastitis is one of the most costly production diseases in the dairy industry that is caused by a wide array of microorganisms. In this review, we focus on the Gram-negative Escherichia coli infections that often occur at periods when the innate immune defence mechanisms are impaired (i.e., parturition through the first 60 days of lactation). There is substantial evidence demonstrating that at these periods, the expected influx of ...
Association between management practices and estimated mastitis incidence and milk losses on robotic dairy farms KU Leuven
This study aims to describe the relation between farm-level management factors and estimated farm-level mastitis incidence and milk loss traits (MIMLT) at dairy farms with automated milking systems. In this observational study, 43 commercial dairy farms in Belgium and the Netherlands were included and 148 ‘management and udder health related variables’ were obtained during a farm visit through a farm audit and survey. The MIMLT were estimated ...
Characterization of the Bacteriophage-Derived Endolysins PlySs2 and PlySs9 with In Vitro Lytic Activity against Bovine MastitisStreptococcus uberis KU Leuven Universiteit Gent
Bovine mastitis, an infection of the cow's mammary gland, is frequently caused by Streptococcus uberis and causes major economic losses in the dairy industry. The intramammary administration of antibiotics currently remains the predominant preventive and therapeutic measure. These antimicrobial compounds, of which some are considered critical in human health care, are frequently applied as dry therapy resulting in their consistent overuse. ...
Associations between CXCR1 polymorphisms and pathogen-specific incidence rate of clinical mastitis, test-day somatic cell count, and test-day milk yield KU Leuven Universiteit Gent
The CXCR1 gene plays an important role in the innate immunity of the bovine mammary gland. Associations between single nucleotide polymorphisms (SNP) CXCR1c.735C>G and c.980A>G and udder health have been identified before in small populations. A fluorescent multiprobe PCR assay was designed specifically and validated to genotype both SNP simultaneously in a reliable and cost-effective manner. In total, 3,106 cows from 50 commercial Flemish ...
Tuberculous mastitis presenting as a lump Universiteit Antwerpen
Tuberculosis (TB) of the breast is a rare entity, and can be confused with many other breast disorders, like mamma carcinoma or inflammatory breast cancer. When finding granulomatous mastitis (GM) on histology, it is important to make a differential diagnosis and seek actively for clues on the presence of tuberculosis, sarcoidosis, Wegener's granulomatosis, or idiopathic granulomatous mastitis, since treatment strategies differ and maltreatment ...