Publicaties
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Identification of Circulating Fibrocytes and Dendritic Derivatives in Corneal Endothelium of Patients With Fuchs' Dystrophy KU Leuven
Fuchs' endothelial corneal dystrophy (FECD) is a degenerative eye disorder affecting 4% of Americans older than 40. It is the leading indication for corneal endothelial (CE) transplantation for which there is a global donor shortage. This study aimed to gain further insight into the pathophysiology of FECD and identify targets for nonsurgical therapy.
High performing immobilized Baeyer-Villiger monooxygenase and glucose dehydrogenase for the synthesis of epsilon-caprolactone derivative KU Leuven
© 2019 Elsevier B.V. The industrial application of Baeyer-Villiger monooxygenases (BVMOs) is typically hindered by stability and cofactor regeneration considerations. The stability of biocatalysts can be improved by immobilization. The goal of this study was to evaluate the (co)-immobilization of a thermostable cyclohexanone monooxygenase from Thermocrispum municipale (TmCHMO) with a glucose dehydrogenase (GDH) from Thermoplasma acidophilum for ...
Sugar and SPY(ce): Large-scale identification of SPINDLY-dependent O-fucosylation targets in Arabidopsis Universiteit Hasselt
Besides their essential roles as substrates for carbon and energy metabolism, sugars also act in signal transduction, coordinating developmental and metabolic processes with nutrient availability. In animals, posttranslational modifications of nucleocytoplasmic proteins with β-N-acetylglucosamine (GlcNAc; an amide derivative of glucose) by O-GlcNac transfer-ase (OGT) play a key role in nutrient sensing (Liu et al. 2015). The Arabidopsis ...
Safety of 2 '-fucosyllactose (2'-FL) produced by a derivative strain (APC199) of Corynebacterium glutamicum ATCC 13032 as a novel food pursuant to Regulation (EU) 2015/2283 Universiteit Gent
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 2 '-fucosyllactose (2'-FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human-identical milk oligosaccharide (HiMO) 2'-FL, but it also contains D-lactose, L-fucose, 3-fucosyllactose, difucosyllactose, D-glucose and D-galactose. The NF is produced by ...
Safety of 3-fucosyllactose (3-FL) produced by a derivative strain of Escherichia coli BL21 (DE3) as a novel food pursuant to Regulation (EU) 2015/2283 Universiteit Gent
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 3-fucosyllactose (3-FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human-identical milk oligosaccharide (HiMO) 3-FL, but it also contains d-lactose, l-fucose, d-glucose and d-galactose, and a small fraction of other related saccharides. The NF is ...
In patients with controlled acromegaly, indices of glucose homeostasis correlate with IGF-1 levels rather than with type of treatment Universiteit Gent
Strategy for the enzymatic acylation of the apple flavonoid phloretin based on prior α-glucosylation Universiteit Gent
The acylation of flavonoids serves as a means to alter their physicochemical properties, enhance their stability, and improve their bioactivity. Compared with natural flavonoid glycosides, the acylation of nonglycosylated flavonoids presents greater challenges since they contain fewer reactive sites. In this work, we propose an efficient strategy to solve this problem based on a first α-glucosylation step catalyzed by a sucrose phosphorylase, ...
The synthesis of 3,4-dideoxy-3,4-difluoro-D-glucose Universiteit Gent
The H2S-releasing naproxen derivative ATB-346 and the slow-release H2S donor GYY4137 reduce intestinal inflammation and restore transit in postoperative ileus Universiteit Gent
Objective: Intestinal inflammation triggers postoperative ileus (POI), commonly seen after abdominal surgery and characterized by impaired gastrointestinal transit; when prolonged, this leads to increased morbidity. Hydrogen sulfide (H2S) is recognized as an important mediator of many (patho) physiological processes, including inflammation, and is now investigated for anti-inflammatory application. Therefore, the aim of this study was to ...