Publicaties
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Experimental validation and docking studies of flavone derivatives on aldose reductase involved in diabetic retinopathy, neuropathy, and nephropathy KU Leuven
The enzyme aldoreductase which plays an important role in pathogenesis of diabetic retinopathy, neuropathy, and nephropathy was purified from bovine lens, and its inhibitory activity was studied with the synthesized flavone derivatives 1-(2-hydroxyphenyl)ethanone as the starting material. Experimental study revealed that 2-chloroflavone shows less inhibitory activity of 60-70% than other flavones used in the study. To validate experimental ...
Inhibitory effect of natural flavone luteolin on Streptococcus mutans biofilm formation KU Leuven
Streptococcus mutans is one of the key pathogens responsible for dental caries, which is known to be one of the most prevalent biofilm-associated diseases worldwide. S. mutans virulence strongly depends on its biofilm formation and enamel demineralization abilities due to the production of surface adhesins, exopolysaccharides, and acid in the presence of sugar. Luteolin is an abundant natural flavone with a prominent anti-bacterial function. ...
Luteolin, a bioactive flavone compound extracted from **Cichorium endivia** L. subsp. divaricatum alleviates the harmful effect of salinity on maize Universiteit Antwerpen
The flavone luteolin was extracted, isolated and purified from leaves of Cichorium endivia L. subsp. divaricatum and identified based on 1H and 13C NMR spectral analyses. Luteolin (0.0015 %) was applied to two cultivars of maize (Giza 2 and single cross 10) grains, germinated in the absence and presence of NaCl, in order to assess the bioactivity of luteolin and its role in alleviating the harmful effect of salt stress on maize. The results ...
A new flavone sulfonic acid from Phyllanthus urinaria Vrije Universiteit Brussel
Antioxidant flavone glycosides from the leaves of Fargesia robusta Universiteit Gent
Flavonol glycosides from the leaves of **Boldoa purpurascens** and their anti-inflammatory properties Universiteit Antwerpen
Boldoa purpurascens is used in Latin America and the Caribbean as a potent diurectic. Phytochemical analysis has shown the presence of flavonoids and other active compounds. In the present work, three flavonol glycosides were isolated from the leaves of the plant. Their structures have been determined by mass spectrometry and by 1D and 2D NMR analysis as 6-methoxykaempferol-3-O-[a-L-rhamnopyr- anosyl-(1 ! 2)]-b-D-xylopyranoside (1); ...
The consumption of flavored milk among a children population: the influence of beliefs and the association of brands with emotions Universiteit Gent
Volatile profiles of rapeseed oil flavored with basil, oregano and thyme as a function of flavoring conditions Universiteit Gent
A novel flavonol glycoside and six derivatives of quercetin and kaempferol from Clematis flammula with antioxidant and anticancer potentials KU Leuven
Clematis flammula leaves are traditionally used in Algeria to treat rheumatoid arthritis. Our aim was to identify the main compounds in this plant in order to characterize its antioxidant and anticancer activities. A new flavonol compound, kaempferol 3-O-[(6-O- caffeoyl)- glucosyl(1 → 2)]-(6-Ocaffeoyl) glucoside-7-O-rhamnoside (6) along with six known flavonol molecules were isolated from an ethanolic extract of Clematis flammula leaves. The ...