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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Universiteit Hasselt Universiteit Antwerpen Universiteit Gent KU Leuven
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount ...
Integrating automated liquid handling in the separation workflow of extracellular vesicles enhances specificity and reproducibility Universiteit Gent
Background Extracellular vesicles (EV) are extensively studied in human body fluids as potential biomarkers for numerous diseases. Major impediments of EV-based biomarker discovery include the specificity and reproducibility of EV sample preparation as well as intensive manual labor. We present an automated liquid handling workstation for the density-based separation of EV from human body fluids and compare its performance to manual handling by ...
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics Universiteit Gent KU Leuven Vlaams Instituut voor Biotechnologie
The brain is protected against invading organisms and other unwanted substances by tightly regulated barriers. However, these central nervous system (CNS) barriers impede the delivery of drugs into the brain via the blood circulation and are therefore considered major hurdles in the treatment of neurological disorders. Consequently, there is a high need for efficient delivery systems that are able to cross these strict barriers. While most ...
Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders Universiteit Gent Vlaams Instituut voor Biotechnologie
Regulation of intercellular communication via extracellular tumor vesicles generated under the influence of elastokines KU Leuven
Pancreatic cancer is currently the fourth leading cause of cancer death in Europe. Pancreatic cancer is a tumor with a very poor prognosis, even if surgery is possible. Pancreatic cancer is characterized by the presence of a transformed microenvironment. This transformed microenvironment involves inflammatory remodelling of the stroma of tissue. This results in accumulation of activated fibroblasts and degradation of the extracellular matrix, in ...
Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts Universiteit Antwerpen Universiteit Gent
Extracellular vesicles (EVs) and their cargo microRNAs (miRNAs) are important regulators of embryo development to the blastocyst stage and beyond. Before implantation can take place, hatching of blastocysts from their zona pellucida is required. However, underlying mechanisms by which blastocyst formation and hatching are initiated remain largely unknown. Here, we provide evidence that embryonic EVs containing bta-miR-378a-3p play a crucial role ...