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Day 5 vs day 6 single euploid blastocyst frozen embryo transfers Vrije Universiteit Brussel

Andrea Abdala, Ibrahim ElKhatib, Aşina Bayram, Ana Arnanz, Laura Melado, Barbara Lawrenz, Human Mousavi Fatemi, Neelke De Munck

OBJECTIVE: To determine which variables affect most the clinical pregnancy rate with positive fetal heartbeat (CPR FHB+) when frozen embryo transfer (FET) cycles are performed with day 5 (D5) or day 6 (D6) euploid blastocysts. Design and method A single center retrospective study was performed from March 2017 till February 2021 including all single FET cycles with euploid D5 or D6 blastocysts and transferred in natural cycles (NC) or hormone ...

Antimüllerian hormone (AMH) and age as predictors of preimplantation genetic testing for aneuploidies (PGT-A) cycle outcomes and blastocyst quality on day 5 in women undergoing in vitro fertilization (IVF) Vrije Universiteit Brussel

A Arnanz, A Bayram, I Elkhatib, A Abdala, Manesh R. Patel, B. Lawrenz, L Melado, HM Fatemi, Neelke De Munck

Purpose: The objective of this study was to investigate whether women with diminished ovarian reserve who planned for PGT-A exhibit a lower number of blastocysts for biopsy, ploidy outcomes, and blastocyst quality on day 5, regardless of age. Methods: A retrospective analysis was performed between March 2017 and July 2020 at ART Fertility Clinics Abu Dhabi, including couples that were triggered for final oocyte maturation in an ovarian ...

Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing Vrije Universiteit Brussel

Rossella Mazzilli, Danilo Cimadomo, Alberto Vaiarelli, Antonio Capalbo, Lisa Dovere, Erminia Alviggi, Ludovica Dusi, Carlo Foresta, Francesco Lombardo, Andrea Lenzi, et al.

OBJECTIVE: To evaluate the impact of the male factor on the outcomes of intracytoplasmic sperm injection (ICSI) cycles combined with preimplantation genetic testing for aneuploidies (PGT-A).

DESIGN: Observational longitudinal cohort study.

SETTING: Private in vitro fertilization (IVF) center.

PATIENT(S): A total of 1,219 oocyte retrievals divided into five study groups according to sperm parameters: normozoospermia ...

Implicit bias in diagnosing mosaicism amongst preimplantation genetic testing providers : results from a multicenter study of 36 395 blastocysts Universiteit Gent

Mina Popovic, Lorena Borot, Aline R. Lorenzon, Ana Luiza Rossi de Castro Lopes, Denny Sakkas, Belen Lledo, Ruth Morales, Jose Antonio Ortiz, Nikolaos Polyzos, Monica Parriego, et al.
STUDY QUESTION: Does the diagnosis of mosaicism affect ploidy rates across different providers offering preimplantation genetic testing for aneuploidies (PGT-A)?SUMMARY ANSWER: Our analysis of 36 395 blastocyst biopsies across eight genetic testing laboratories revealed that euploidy rates were significantly higher in providers reporting low rates of mosaicism.WHAT IS KNOWN ALREADY: Diagnoses consistent with chromosomal mosaicism have emerged as ...

How to identify patients who would benefit from delayed-matured oocytes insemination Vrije Universiteit Brussel

I Elkhatib, Daniela Nogueira, A Bayram, A Abdala, R Del Gallego, L Melado, Neelke De Munck, B. Lawrenz, HM Fatemi

STUDY QUESTION: Which patients might benefit from insemination of delayed-matured oocytes?

SUMMARY ANSWER: Delayed-matured oocytes had a ≥50% contribution to the available cohort of biopsied blastocysts in patients with advanced maternal age, low maturation, and/or low fertilization rates.

WHAT IS KNOWN ALREADY: Retrieved immature oocytes that progress to the MII stage in vitro could increase the number of embryos available ...

Chromosomal mosaicism in human blastocysts : the ultimate diagnostic dilemma Universiteit Gent

Mina Popovic, Lien Dhaenens, Annekatrien Boel, Björn Menten, Björn Heindryckx
BACKGROUND: Trophectoderm (TE) biopsy and next generation sequencing (NGS) are currently the preferred techniques for preimplantation genetic testing for aneuploidies (PGT-A). Although this approach delivered important improvements over previous testing strategies, increased sensitivity has also prompted a rise in diagnoses of uncertain clinical significance. This includes reports of chromosomal mosaicism, suggesting the presence of ...

The effect of late-follicular phase progesterone elevation on embryo ploidy and cumulative live birth rates Universiteit Gent

Ana Raquel Neves, Samuel Santos-Ribeiro, Sandra Garcia-Martinez, Marta Devesa, Sergio R. Soares, Juan Antonio Garcia-Velasco, Nicolas Garrido, Nikolaos Polyzos
Research question: Does late-follicular phase progesterone elevation have a deleterious effect on embryo euploidy, blastocyst formation rate and cumulative live birth rates (CLBR)? Design: A multicentre retrospective cross-sectional study including infertile patients aged 18-40 years who underwent ovarian stimulation in a gonadotrophin-releasing hormone antagonist protocol and preimplantation genetic testing for aneuploidies (PGT-A) followed by ...

Genome-wide equine preimplantation genetic testing enabled by simultaneous haplotyping and copy number detection Universiteit Gent KU Leuven

Tine De Coster, Y. Zhao, O. Tsuiko, S. Demyda-Peyras, Ann Van Soom, J. R. Vermeesch, Katrien Smits
In different species, embryonic aneuploidies and genome-wide errors are a major cause of developmental failure. The increasing number of equine embryos being produced worldwide provides the opportunity to characterize and rank or select embryos based on their genetic profile prior to transfer. Here, we explored the possibility of generic, genome-wide preimplantation genetic testing concurrently for aneuploidies (PGT-A) and monogenic (PGT-M) ...

Severe male factor in in vitro fertilization Vrije Universiteit Brussel

Rossella Mazzilli, Alberto Vaiarelli, Lisa Dovere, Danilo Cimadomo, Nicolò Ubaldi, Susanna Ferrero, Laura Rienzi, Francesco Lombardo, Andrea Lenzi, Herman Tournaye, et al.

Infertility affects 10%-15% of couples worldwide. Of all infertility cases, 20%-70% are due to male factors. In the past, men with severe male factor (SMF) were considered sterile. Nevertheless, the development of intracytoplasmic sperm injection (ICSI) drastically modified this scenario. The advances in assisted reproductive technology (ART), specifically regarding surgical sperm retrieval procedures, allowed the efficacious treatment of ...

The Ratio of Serum Progesterone (P4) to the Number of Follicles (P4/follicle) is a More Objective Parameter for Euploidy Rate as Compared to Systemic Progesterone Levels Vrije Universiteit Brussel

Khaled Ibrahim Abu Ali, Barbara Lawrenz, Upma Shanker, Francisco Ruiz, Ibrahim ElKhatib, Human Fatemi, Neelke De Munck

Does the late follicular phase progesterone (P4) and the P4-to-follicle-ratio affect the ploidy state of the biopsied embryos? A retrospective observational study conducted at ART Fertility Clinics Abu Dhabi and Muscat, including all stimulation cycles performed between January 2015 and December 2019. In total, 975 cycles were considered for this study. Inclusion criteria were ovarian stimulation due to primary/secondary infertility, ...