Publicaties
Gekozen filters:
Gekozen filters:
eQTL set–based association analysis identifies novel susceptibility loci for Barrett esophagus and esophageal adenocarcinoma Universiteit Antwerpen
Background: Over 20 susceptibility single-nucleotide poly-morphisms (SNP) have been identified for esophageal adenocarcinoma (EAC) and its precursor, Barrett esophagus (BE), explaining a small portion of heritability.Methods: Using genetic data from 4,323 BE and 4,116 EAC patients aggregated by international consortia including the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), we conducted a comprehensive transcriptome-wide ...
Challenges of using qPCR for eQTL mapping Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Flower colour is inherited as a semi-qualitative trait in azalea and is mainly determined by differences in anthocyanins and flavonols. A two-gene model is used to explain the phenotypic variation between white, brick red and carmine red colour: W in case the flower petals contain anthocyanins and Q if flavonols are present as co-pigments. However, the regulatory network behind this pathway is still unclear. To identify key driver genes of ...
eQTL mapping of candidate genes for flower colour as a model for genetical genomics in azalea Instituut voor Landbouw-, Visserij- en Voedingsonderzoek
Flower colour in azalea is inherited as a semi-qualitative trait and is mainly determined by differences in anthocyanins and flavonols. A two-gene model is used to explain the phenotypic variation between white, brick red and carmine red colour: W in case the flower petals contain anthocyanins and Q if flavonols are present as co-pigments. However, the regulatory network behind this pathway is still unclear. To identify key driver genes of the ...
EPSILON: an eQTL prioritization framework using similarity measures derived from local networks KU Leuven Universiteit Gent
MOTIVATION: When genomic data are associated with gene expression data, the resulting expression quantitative trait loci (eQTL) will likely span multiple genes. eQTL prioritization techniques can be used to select the most likely causal gene affecting the expression of a target gene from a list of candidates. As an input, these techniques use physical interaction networks that often contain highly connected genes and unreliable or irrelevant ...
Integrative eQTL analysis of tumor and host omics data in individuals with bladder cancer KU Leuven
Integrative analyses of several omics data are emerging. The data are usually generated from the same source material (i.e., tumor sample) representing one level of regulation. However, integrating different regulatory levels (i.e., blood) with those from tumor may also reveal important knowledge about the human genetic architecture. To model this multilevel structure, an integrative-expression quantitative trait loci (eQTL) analysis applying ...
An eQTL biological data visualization challenge and approaches from the visualization community KU Leuven
In 2011, the IEEE VisWeek conferences inaugurated a symposium on Biological Data Visualization. Like other domain-oriented Vis symposia, this symposium's purpose was to explore the unique characteristics and requirements of visualization within the domain, and to enhance both the Visualization and Bio/Life-Sciences communities by pushing Biological data sets and domain understanding into the Visualization community, and well-informed ...
eQTL mapping of candidate genes for flower colour as a model for genetical genomics in Azalea Universiteit Gent
By its production of approximately 40 million plants per year, azalea (Rhododendron simsii hybrids) is the most important flowering pot plant in Belgium . Flower colour is one of the most important features for azalea breeding. In azalea, flower colour is inherited as a semi-qualitative trait and is mainly determined by differences in anthocyanin and flavonol levels. Its segregation pattern could be explained by a two-gene model (Heursel and ...