Publicaties
Fast and optimal algorithm for case-control matching using registry data: application on the antibiotics use of colorectal cancer patients Universiteit Hasselt KU Leuven
Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer : a post hoc analysis of two non-randomized phase II trials Universiteit Gent KU Leuven Universiteit Antwerpen
Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia Vrije Universiteit Brussel
BACKGROUND: A substantial fraction of familial colorectal cancer (CRC) and polyposis heritability remains unexplained. This study aimed to identify predisposing loci in patients with these disorders.
METHODS: Homozygosity mapping was performed using 222 563 SNPs in 302 index patients with various colorectal neoplasms and 3367 controls. Linkage analysis, exome and whole-genome sequencing were performed in a family affected by ...
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer Vrije Universiteit Brussel
Germline variants affecting the exonuclease domains of POLE and POLD1 predispose to multiple colorectal adenomas and/or colorectal cancer (CRC). The aim of this study was to estimate the prevalence of previously described heterozygous germline variants POLE c.1270C>G, p.(Leu424Val) and POLD1 c.1433G>A, p.(Ser478Asn) in a Dutch series of unexplained familial, early onset CRC and polyposis index cases. We examined 1188 familial CRC and ...
The use of Oxaliplatin or Mitomycin C in HIPEC treatment for peritoneal carcinomatosis from colorectal cancer: A comparative study Universiteit Hasselt KU Leuven
Colorectal cancer screening knowledge, attitudes and behavioural intention among Indigenous Western Australians Instituut voor Tropische Geneeskunde
BACKGROUND: Indigenous Australians are significantly less likely to participate in colorectal cancer (CRC) screening compared to non-Indigenous people. This study aimed to identify important factors influencing the decision to undertake screening using Faecal Occult Blood Testing (FOBT) among Indigenous Australians. Very little evidence exists to guide interventions and programmatic approaches for facilitating screening uptake in this ...
Progression-free survival as a primary endpoint in clinical trials of metastatic colorectal cancer Universiteit Hasselt
Introduction to molecular and clinical genetics of colorectal cancer syndromes Vrije Universiteit Brussel
The understanding of molecular genetics in the field of gastroenterology has rapidly grown over the last two decades. In recent years many genes involved in the disorders of the gastrointestinal (GI) tract such as colorectal cancer (CRC) and inflammatory bowel disease have been identified. The elucidation of the molecular genetics of these diseases made it possible to study the high-penetrance susceptibility genes for disease-causing ...
An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy Vrije Universiteit Brussel
PATIENTS AND METHODS: This open-label extension study evaluated panitumumab monotherapy in BSC patients with radiographically documented disease progression in the ...