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Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes KU Leuven
Cholangiocellular carcinoma (CC) originates from topographically heterogeneous cholangiocytes. The cylindrical mucin-producing cholangiocytes are located in large bile ducts and the cuboidal non-mucin producing cholangiocytes are located in ductules containing bipotential hepatic progenitor cells (HPCs). We investigated the clinicopathological and molecular features of 85 resected CCs [14 hilar CCs (so-called Klatskin tumor), 71 intrahepatic CCs ...
Combined hepatocellular and cholangiocellular carcinoma presenting with radiological characteristics of focal nodular hyperplasia. Vrije Universiteit Brussel
Combined hepatocellular and cholangiocellular carcinoma with radiological characteristics of focal nodular hyperplasia Universiteit Gent
HEPATOCYTIC DIFFERENTIATION IN CHOLANGIOCELLULAR CARCINOMA SUGGESTING HEPATIC PROGENITOR CELL ORIGIN KU Leuven
The expression of hepatic transport proteins in progenitor cells and liver tumours : diagnostic and pathogenetic implications KU Leuven
Levertransporteiwitten zijn betrokken in belangrijke fysiologische funct ies van de lever door het transport van een brede waaier van endogene en exogene substraten over de celmembraan. De aanwezigheid van leden van d e ATP-binding cassette (ABC) transportfamilie in tumoren, zorgen ervoor dat een brede waaier van structurele en functioneel ongerelateerde chemo therapeutica uit de kankercel worden getransporteerd zodat de cellen res istent worden ...
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin KU Leuven
Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is thought to originate from the ductules/canals of Hering, where hepatic progenitor cells (HPCs) are located. We investigated the clinicopathological features of 30 CLCs and their relationship to HPCs. We evaluated the expression of hepatocytic markers (hepatocyte paraffin-1, canalicular polyclonal carcinoembryonic antigen, and CD10), biliary/HPC markers ...