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TUMOUR PROGRESSION OF CUTANEOUS SQUAMOUS CELL CARCINOMA: RESPONSE TO CHEMOTHERAPEUTICS AND REGULATION OF THE EPITHELIAL-MESENCHYMAL TRANSITION PROCESS KU Leuven
Although most of the cutaneous squamous cell carcinomas (SCCs) can be cured, a subset of patients develops advanced disease, with high risk for metastasis. The induction of invasion and metastasis by epithelial-mesenchymal transition, as well as the failure to eliminate the (metastatic) cancer cells due to resistance to therapy plays a major role in the lethal outcome of advanced cutaneous squamous cell carcinoma. EMT and chemoresistance, 2 ...
The effects of the clinically applicable chemotherapeutics on theimmunogenicity of melanoma cell death. KU Leuven
During carcinogenesis, cancer cells that are efficiently recognised by the immune system are removed, while the variants capable of evading host defence systems form an aggressive tumour. Currently, it is becoming widely accepted that an effective anticancer therapy should reverse the immunoevasive and immunosuppressive effects elicited by the cancer cells and activate anticancer immune responses that will efficiently eliminate cancerous lesions ...
Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics Universiteit Gent Vlaams Instituut voor Biotechnologie
The most lethal form of skin cancer is cutaneous melanoma, a tumor that develops in the melanocytes, which are found in the epidermis. The treatment strategy of melanoma is dependent on the stage of the disease and often requires combined local and systemic treatment. Over the years, systemic treatment of melanoma has been revolutionized and shifted toward immunotherapeutic approaches. Phototherapies like photothermal therapy (PTT) have gained ...
Trial Watch: Immunogenic cell death induction by anticancer chemotherapeutics KU Leuven
The expression "immunogenic cell death" (ICD) refers to a functionally unique form of cell death that facilitates (instead of suppressing) a T cell-dependent immune response specific for dead cell-derived antigens. ICD critically relies on the activation of adaptive responses in dying cells, culminating with the exposure or secretion of immunostimulatory molecules commonly referred to as "damage-associated molecular patterns". Only a few agents ...
Clinically relevant chemotherapeutics have the ability to induce immunogenic cell death in non-small cell lung cancer Universiteit Antwerpen
The concept of immunogenic cell death (ICD) has emerged as a cornerstone of therapy-induced anti-tumor immunity. To this end, the following chemotherapies were evaluated for their ability to induce ICD in non-small cell lung cancer (NSCLC) cell lines: docetaxel, carboplatin, cisplatin, oxaliplatin and mafosfamide. The ICD hallmarks ATP, ecto-calreticulin, HMGB1, phagocytosis and maturation status of dendritic cells (DCs) were assessed in vitro. ...
De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation KU Leuven
Activation of de novo lipogenesis in cancer cells is increasingly recognized as a hallmark of aggressive cancers and has been implicated in the production of membranes for rapid cell proliferation. In the current report, we provide evidence that this activation has a more profound role. Using a mass spectrometry-based phospholipid analysis approach, we show that clinical tumor tissues that display the lipogenic phenotype show an increase in the ...
Hyperthermia enhances efficacy of chemotherapeutic agents in pancreatic cancer cell lines Universiteit Antwerpen KU Leuven
Chemotherapy (CT) is the standard care for advanced pancreatic ductal adenocarcinoma (PDAC); however, with limited efficacy. Hyperthermia (HT) treatment has been suggested as a sensitizer to improve outcomes. However, the direct effect of the HT and CT combination is not fully understood. Therefore, we aim to assess the direct cytotoxic effect of HT in PDAC cells as monotherapy or in combination with chemotherapeutics. Different temperatures ...
Genetic and epigenetic modifications induced by chemotherapeutic drugs: human amniotic fluid stem cells as an in-vitro model KU Leuven
BACKGROUND: Bleomycin, etoposide and cisplatin (BEP) are three chemotherapeutic agents widely used individually or in combination with each other or other chemotherapeutic agents in the treatment of various cancers. These chemotherapeutic agents are cytotoxic; hence, along with killing cancerous cells, they also damage stem cell pools in the body, which causes various negative effects on patients. The epigenetic changes due to the individual ...