Publicaties
Instruction of myeloid cells by the tumor microenvironment: Open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations. Vrije Universiteit Brussel
Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma Universiteit Gent
Impact of the variable killer Ig-like receptor-human leukocyte antigen interactions on natural killer cell cytotoxicity toward foreign CD4 T cells Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Background: Natural killer (NK) cells are known to mount a response against foreign target cells, where the absence of the dominant inhibitory killer Ig-like receptor (KIR)-human leukocyte antigen (HLA) interaction immensely lowers the threshold for NK cell activation. NK cells could thus constitute a vital part in the mucosal defense against cell-associated sexually transmitted diseases. Here, we performed a detailed analysis of hitherto ...
In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression Vrije Universiteit Brussel
There is currently a shortage of organ donors available for pancreatic beta cell transplantation into diabetic patients. An alternative source of beta cells is pre-existing pancreatic cells. While we know that beta cells can arise directly from alpha cells during pancreatic regeneration we do not understand the molecular basis for the switch in phenotype. The aim of the present study was to investigate if hepatocyte nuclear factor 4 alpha ...