Determination of the Variability and Associated Epigenetic Signature of Tandem Repeats by Single Molecule Sequencing KU Leuven
Around 1.5 million short tandem repeats (STRs) are spread across the entire human genome. STRs are functionally important elements that are able to modulate the phenotype of an individual. They can modify cellular biology by influencing the genome, transcriptome and proteome of a cell. The most extreme examples of the functional impact of STRs are the more than 40 repeat expansion disorders like fragile X syndrome (FXS) and myotonic dystrophy 1 ...