Minimal functional β-cell mass in intraportal implants that reduces glycemic variability in type 1 diabetic recipients Vrije Universiteit Brussel Universiteit Antwerpen KU Leuven
OBJECTIVE: Previous work has shown a correlation between β-cell number in cultured islet cell grafts and their ability to induce C-peptide secretion after intraportal implantation in C-peptide-negative type1 diabetic patients. In this cross-sectional study, we examined the minimal functional β-cell mass (FBM) in the implant that induces metabolic improvement.
RESEARCH DESIGN AND METHODS: Glucose clamps assessed FBM in 42 recipients ...